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Journal of Clinical Microbiology, June 1998, p. 1808-1810, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Positive Result by Serology Indicates Active Helicobacter pylori Infection in Patients with Atrophic Gastritis

Arto Kokkola,1,* Hilpi Rautelin,2 Pauli Puolakkainen,1 Pentti Sipponen,3 Martti Färkkilä,4 Reijo Haapiainen,1 and Timo U. Kosunen2

Second Department of Surgery1 and Department of Bacteriology and Immunology, The Haartman Institute and HD-Diagnostics, University of Helsinki,2 and the Department of Medicine,4 Helsinki University Central Hospital, Helsinki, and Department of Pathology, Jorvi Hospital, Espoo,3 Finland

Received 6 January 1998/Returned for modification 19 February 1998/Accepted 17 March 1998

Patients with atrophic corpus gastritis and elevated Helicobacter pylori antibody titers but 13C-urea breath test (13C-UBT) and histology results negative for H. pylori were randomized into eradication therapy or follow-up only. Antibody levels decreased significantly in six out of seven patients in the eradication group, while in the follow-up group, the titers declined in only one out of eight patients. In patients with atrophic corpus gastritis, positive serology results may indicate an ongoing infection in spite of negative 13C-UBT and histology results.

* Corresponding author. Mailing address: Second Department of Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, FI-00290 Helsinki, Finland. Phone: 358-9-471951602. Fax: 358-9-4714675. E-mail: pauli.puolakkainen{at}huch.fi.

Journal of Clinical Microbiology, June 1998, p. 1808-1810, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Mini, R., Annibale, B., Lahner, E., Bernardini, G., Figura, N., Santucci, A. (2006). Western Blotting of Total Lysate of Helicobacter pylori in Cases of Atrophic Body Gastritis. Clin. Chem. 52: 220-226 [Abstract] [Full Text]  
  • Salomaa-Rasanen, A., Kosunen, T. U., Mattila, J., Sarna, S., Rautelin, H. (2004). Age-Dependent Accuracy of Helicobacter pylori Antibody Assays for Adults, with Special Emphasis on Atrophic Gastritis. CVI 11: 1185-1188 [Abstract] [Full Text]  


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