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Journal of Clinical Microbiology, July 1998, p. 2127-2130, Vol. 36, No. 7
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Borna Disease in a Dog with Lethal Meningoencephalitis

Herbert Weissenböck,1,* Norbert Nowotny,2 Patrick Caplazi,3 Jolanta Kolodziejek,2 and Felix Ehrensperger3

Institute of Pathology and Forensic Veterinary Medicine1 and Institute of Virology,2 University of Veterinary Medicine, A-1210 Vienna, Austria, and Institute of Veterinary Pathology, University of Zurich, CH-8057 Zurich, Switzerland3

Received 4 February 1998/Returned for modification 9 April 1998/Accepted 20 April 1998

A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.

* Corresponding author. Mailing address: Institute of Pathology and Forensic Veterinary Medicine, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna, Austria. Phone: 43 1 25077 2418. Fax: 43 1 25077 2490. E-mail: Herbert.Weissenboeck{at}vu-wien.ac.at.

Journal of Clinical Microbiology, July 1998, p. 2127-2130, Vol. 36, No. 7
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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