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Journal of Clinical Microbiology, July 1998, p. 2140-2142, Vol. 36, No. 7
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Therapeutic Effect of Doxycycline in Experimental Subclinical Canine Monocytic Ehrlichiosis: Evaluation of a 6-Week Course

Shimon Harrus,1,* Trevor Waner,2 Itzhak Aizenberg,1 and Hylton Bark1

Department of Clinical Sciences, Veterinary Teaching Hospital, Hebrew University of Jerusalem, Rehovot 76100,1 and Israel Institute for Biological Research, Ness Ziona,2 Israel

Received 16 October 1997/Returned for modification 6 March 1998/Accepted 9 April 1998

The efficacy of doxycycline treatment (10 mg/kg of body weight every 24 h for 42 days) in eliminating Ehrlichia canis from four subclinically infected dogs was evaluated. One dog remained PCR positive, suggesting that 6 weeks of doxycycline treatment may not be sufficient to clear E. canis parasites from all subclinically infected dogs. Serology (indirect immunofluorescent antibody assay) was shown to be unreliable in assessing recovery from the carrier state, as anti-E. canis antibodies persisted after elimination of the parasite. Our findings suggest that an increase in the platelet count may be an important indicator for dogs that recover from subclinical ehrlichiosis.

* Corresponding author. Mailing address: Veterinary Teaching Hospital, Department of Clinical Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. Phone: 972-3-9688546. Fax: 972-3-9604079. E-mail: harrus{at}agri.huji.ac.il.

Journal of Clinical Microbiology, July 1998, p. 2140-2142, Vol. 36, No. 7
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Branger, S., Rolain, J. M., Raoult, D. (2004). Evaluation of Antibiotic Susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by Real-Time PCR. Antimicrob. Agents Chemother. 48: 4822-4828 [Abstract] [Full Text]  
  • Harrus, S., Kenny, M., Miara, L., Aizenberg, I., Waner, T., Shaw, S. (2004). Comparison of Simultaneous Splenic Sample PCR with Blood Sample PCR for Diagnosis and Treatment of Experimental Ehrlichia canis Infection. Antimicrob. Agents Chemother. 48: 4488-4490 [Abstract] [Full Text]  
  • Harrus, S., Waner, T., Bark, H., Jongejan, F., Cornelissen, A. W. C. A. (1999). Recent Advances in Determining the Pathogenesis of Canine Monocytic Ehrlichiosis. J. Clin. Microbiol. 37: 2745-2749 [Full Text]  


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