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Journal of Clinical Microbiology, August 1998, p. 2342-2345, Vol. 36, No. 8
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Characterization of Neisseria meningitidis Strains Causing Disease in Complement-Deficient and Complement-Sufficient Patients

C. A. P. Fijen,1,* E. J. Kuijper,1 J. Dankert,1 M. R. Daha,2 and D. A. Caugant3

Department of Medical Microbiology and Reference Laboratory for Bacterial Meningitis, University of Amsterdam, Amsterdam, and RIVM, Bilthoven,1 and Department of Nephrology, University Hospital, Leiden,2 The Netherlands, and World Health Organisation Collaborating Centre for Reference and Research on Meningococci, National Institute of Public Health, Oslo, Norway3

Received 9 February 1998/Returned for modification 5 March 1998/Accepted 24 April 1998

Serotyping and serosubtyping of meningococci showed no difference between isolates from 44 complement-deficient persons and from 50 complement-sufficient persons with meningococcal disease. Multilocus enzyme electrophoretic typing of the meningococci revealed 54 electrophoretic types that were equally distributed among isolates from complement-deficient and complement-sufficient patients. Analysis of strains isolated from eight complement-deficient persons with 11 recurrences of meningococcal disease showed that one strain was identical to the strain previously isolated from the same individual. Our results indicate that there are no differences between the clonal distributions of strains infecting complement-deficient and complement-sufficient patients. Most recurrences were infections caused by different strains.

* Corresponding author. Mailing address: Department of Medical Microbiology, L1-104, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. Phone: (31-20)5665731. Fax: (31-20)6979271. E-mail: c.a.fijen{at}amc.uva.nl.

Journal of Clinical Microbiology, August 1998, p. 2342-2345, Vol. 36, No. 8
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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Copyright © 1998 by the American Society for Microbiology. All rights reserved.