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Journal of Clinical Microbiology, September 1998, p. 2499-2502, Vol. 36, No. 9
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Cat Scratch Disease: the Rare Role of Afipia felis

Michael Giladi,1,* Boaz Avidor,1 Yehudith Kletter,1 Suzy Abulafia,1 Leonard N. Slater,2 David F. Welch,3 Don J. Brenner,4 Arnold G. Steigerwalt,4 Anne M. Whitney,4 and Moshe Ephros5

The Bernard Pridan Laboratory for Molecular Biology of Infectious Diseases, Ichilov Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv,1 and the Department of Pediatrics, Carmel Medical Center, Haifa,5 Israel; University of Oklahoma, Health Sciences Center, Oklahoma City, Oklahoma2; Laboratory Corporation of America, and Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, Texas3; and Meningitis and Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia4

Received 15 January 1998/Returned for modification 19 February 1998/Accepted 22 May 1998

Since its isolation in 1988, Afipia felis has been associated with cat scratch disease (CSD) in only one report and its role in CSD has been questioned. We have cultured A. felis from a lymph node of a patient with CSD. 16S rRNA gene sequencing, DNA relatedness studies, fatty acid analysis, and PCR of the A. felis ferredoxin gene showed that the isolate is identical to the previously reported A. felis isolate. To determine the role of A. felis in CSD, PCR of the 16S rRNA gene followed by hybridizations with specific probes were performed with lymph node specimens from CSD patients. All 32 specimens tested positive for Bartonella henselae and negative for A. felis. We conclude that A. felis is a rare cause of CSD. Diagnostic tests not conducive to the identification of A. felis might cause the diagnosis of CSD due to A. felis to be missed.

* Corresponding author. Mailing address: The Bernard Pridan Laboratory for Molecular Biology of Infectious Diseases, Ichilov Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman St., Tel Aviv 64239, Israel. Phone: 972-3-6973851. Fax: 972-3-6973850. E-mail: giladi{at}tasmc.health.gov.il.

Journal of Clinical Microbiology, September 1998, p. 2499-2502, Vol. 36, No. 9
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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