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Journal of Clinical Microbiology, September 1998, p. 2571-2574, Vol. 36, No. 9
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Prevalence of Astroviruses in a Children's Hospital

Sunita Shastri, Anne Martin Doane, Jaime Gonzales, Usha Upadhyayula, and Dorsey M. Bass*

Department of Pediatrics and Center for Digestive Disease, Stanford University, Stanford, California 94305-5208

Received 26 November 1997/Returned for modification 30 January 1998/Accepted 19 June 1998

An enzyme immunoassay for astrovirus was used to screen 357 stool samples from 267 symptomatic inpatients at a tertiary-care children's hospital. Thirty stool samples from 26 patients contained astrovirus antigen, while rotavirus was found in 34 samples and Clostridium difficile toxin was found in 40. Half of the astrovirus infections were nosocomial. Additional pathogens were identified in six of the astrovirus antigen-positive stool samples. Most (80%) of the astroviruses recovered were of serotype 1. Astrovirus infections were significantly more common than rotavirus or C. difficile infections in very young infants and in those with surgical short-bowel syndrome.

* Corresponding author. Mailing address: Department of Pediatrics and Center for Digestive Disease, Stanford University, Stanford, CA 94305-5208. Phone: (650) 723-5070. Fax: (650) 723-2137. E-mail: Dorsey.Bass{at}Forsythe.stanford.edu.

Journal of Clinical Microbiology, September 1998, p. 2571-2574, Vol. 36, No. 9
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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