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Journal of Clinical Microbiology, January 1999, p. 122-126, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

New York 1 and Sin Nombre Viruses Are Serotypically Distinct Viruses Associated with Hantavirus Pulmonary Syndrome

Irina Gavrilovskaya,1 Rachel LaMonica,1 Mary-Ellen Fay,1 Brian Hjelle,2 Connie Schmaljohn,3 Robert Shaw,1,4 and Erich R. Mackow1,4,5,*

The Department of Medicine1 and the Department of Molecular Genetics and Microbiology,5 Stony Brook University, Stony Brook, New York 11794, Department of Pathology, University of New Mexico, Albuquerque, New Mexico,2 The Northport VA Medical Center, Northport, New York 11768,4 and USAMRIID, Fort Detrick, Maryland3

Received 24 July 1998/Returned for modification 17 September 1998/Accepted 30 September 1998

New York 1 virus (NY-1) and Sin Nombre virus (SN) are associated with hantavirus pulmonary syndrome (HPS). NY-1 and SN are derived from unique mammalian hosts and geographic locations but have similar G1 and G2 surface proteins (93 and 97% identical, respectively). Focus reduction neutralization assays were used to define the serotypic relationship between NY-1 and SN. Sera from NY-1-positive Peromyscus leucopus neutralized NY-1 and SN at titers of >= 1/3,200 and <= 1/400, respectively (n = 12). Conversely, SN-specific rodent sera neutralized NY-1 and SN at titers of <1/400 and 1/6,400, respectively (n = 13). Acute-phase serum from a New York HPS patient neutralized NY-1 (1/640) but not SN (<1/20), while sera from HPS patients from the southwestern United States had 4- to >16-fold-lower neutralizing titers to NY-1 than to SN. Reference sera to Hantaan, Seoul, and Prospect Hill viruses also failed to neutralize NY-1. These results indicate that SN and NY-1 define unique hantavirus serotypes and implicate the presence of additional HPS-associated hantavirus serotypes in the Americas.

* Corresponding author. Mailing address: Department of Medicine/GI, Stony Brook University, HSC T17, Rm. 60, Stony Brook, N.Y. 11794. Phone: 516-444-2120. Fax: 516-444-8886. E-mail: EMackow{at}mail.som.sunysb.edu.

Journal of Clinical Microbiology, January 1999, p. 122-126, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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