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Journal of Clinical Microbiology, January 1999, p. 235-237, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Viral Superinfection in Previously Unrecognized Chronic Carriers of Hepatitis B Virus with Superimposed Acute Fulminant versus Nonfulminant Hepatitis

Chia-Ming Chu,* Chau-Ting Yeh, and Yun-Fan Liaw

Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan

Received 20 May 1998/Returned for modification 3 August 1998/Accepted 13 October 1998

The role of viral superinfection in hepatitis B surface antigen carriers with superimposed fulminant (n = 60) versus nonfulminant (n = 90) acute hepatitis was studied. The frequency of hepatitis A virus (HAV) (0 versus 2.2%), HCV (18.3 versus 21.1%), HDV (15.0 versus 7.8%), and HEV (1.7 versus 4.4%) infection showed no significant difference, while simultaneous HCV and HDV infection was significantly more prevalent in the former (8.3 versus 0%). Only 3.6% of fulminant cases and 3.3% of nonfulminant controls were HGV RNA positive.

* Corresponding author. Mailing address: Liver Research Unit, Chang Gung Memorial Hospital, 199, Tung Hwa North Rd., Taipei, Taiwan. Phone: 886-3-3281200, ext. 8120. Fax: 886-3-3282824. E-mail: gi31208108{at}adm.cgmh.com.tw.

Journal of Clinical Microbiology, January 1999, p. 235-237, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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