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Journal of Clinical Microbiology, January 1999, p. 248-250, Vol. 37, No. 1
Institut für Medizinische Mikrobiologie
und Hygiene1 and
Medizinische Klinik
I,
Received 9 June 1998/Returned for modification 24 July
1998/Accepted 28 September 1998
We describe the identification of Methylobacterium
zatmanii as the causative agent of bacteremia and fever in an
immunocompromised patient. The patient, a 60-year-old man, had a
5-month history of acute myeloid leukemia and had been on
chemotherapy throughout this period. Seven days after the onset of
neutropenia, the patient developed fever. The combination of
ciprofloxacin, co-trimoxazole, imipenem, amikacin, and vancomycin led
to a complete defervescence. On subculture from six positive blood
cultures, the organism grew only on buffered charcoal yeast extract
agar and not on standard agars. Identification by universal PCR
and subsequent sequence analysis of the amplified 16S rRNA
gene segment was achieved. This identification by molecular
biology techniques was confirmed by conventional biochemical tests. To
our knowledge, this is the first description of M. zatmanii
isolated from patient material.
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Systemic Infection of an Immunocompromised
Patient with Methylobacterium zatmanii
*
Corresponding author. Present address:
Hygiene-Institut, Universität Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Phone: 49-228-2875535. Fax: 49-228-2875645. E-mail:
horney{at}mailer.meb.uni-bonn.de.
Journal of Clinical Microbiology, January 1999, p. 248-250, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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