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Journal of Clinical Microbiology, January 1999, p. 248-250, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Systemic Infection of an Immunocompromised Patient with Methylobacterium zatmanii

B. Hornei,1,* E. Lüneberg,2 H. Schmidt-Rotte,2 M. Maaß,1 K. Weber,3 F. Heits,3 M. Frosch,2 and W. Solbach1

Institut für Medizinische Mikrobiologie und Hygiene1 and Medizinische Klinik I,3 Medizinische Universität zu Lübeck, Lübeck, and Institut für Hygiene und Mikrobiologie, Universität Würzburg,2 Würzburg, Germany

Received 9 June 1998/Returned for modification 24 July 1998/Accepted 28 September 1998

We describe the identification of Methylobacterium zatmanii as the causative agent of bacteremia and fever in an immunocompromised patient. The patient, a 60-year-old man, had a 5-month history of acute myeloid leukemia and had been on chemotherapy throughout this period. Seven days after the onset of neutropenia, the patient developed fever. The combination of ciprofloxacin, co-trimoxazole, imipenem, amikacin, and vancomycin led to a complete defervescence. On subculture from six positive blood cultures, the organism grew only on buffered charcoal yeast extract agar and not on standard agars. Identification by universal PCR and subsequent sequence analysis of the amplified 16S rRNA gene segment was achieved. This identification by molecular biology techniques was confirmed by conventional biochemical tests. To our knowledge, this is the first description of M. zatmanii isolated from patient material.

* Corresponding author. Present address: Hygiene-Institut, Universität Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Phone: 49-228-2875535. Fax: 49-228-2875645. E-mail: horney{at}mailer.meb.uni-bonn.de.

Journal of Clinical Microbiology, January 1999, p. 248-250, Vol. 37, No. 1
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.