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Journal of Clinical Microbiology, October 1999, p. 3204-3209, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Epidemiological Evidence for Dormant Cryptococcus neoformans Infection

Dea Garcia-Hermoso, Guilhem Janbon,* and Françoise Dromer

Unité de Mycologie, Institut Pasteur, Paris, France

Received 13 May 1999/Returned for modification 28 June 1999/Accepted 22 July 1999

To date, the time of acquisition of a Cryptococcus neoformans infectious strain has never been studied. We selected a primer, (GACA)4, and a probe, CNRE-1, that by randomly amplified polymorphic DNA (RAPD) analysis and restriction fragment length polymorphism (RFLP), respectively, regrouped strains from control samples of C. neoformans var. grubii environmental isolates according to their geographical origins. The two typing techniques were then used to analyze 103 isolates from 29 patients diagnosed with cryptococcosis in France. Nine of the 29 patients lived in Africa a median of 110 months prior to moving to France; 17 of the patients originated from Europe. Results showed a statistically significant clustering of isolate subtypes from patients originating from Africa compared to those from Europe. We conclude that the patients had acquired the C. neoformans infectious strain long before their clinical diagnoses were made.

* Corresponding author. Mailing address: Unité de Mycologie, Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: (33) 1 45688356. Fax: (33) 1 45688420. E-mail: janbon{at}pasteur.fr.

Journal of Clinical Microbiology, October 1999, p. 3204-3209, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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