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Journal of Clinical Microbiology, October 1999, p. 3271-3275, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Isolation of Helicobacter canis from a Colony of Bengal Cats with Endemic Diarrhea

Janet E. Foley,1,2 Stanley L. Marks,1 Linda Munson,3 Ann Melli,1 Floyd E. Dewhirst,4 Shilu Yu,5 Zeli Shen,5 and James G. Fox5,*

Department of Medicine and Epidemiology,1 Center for Companion Animal Health,2 and Department of Pathology, Microbiology, and Immunology,3 School of Veterinary Medicine, University of California, Davis 95616; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 021395; and Forsyth Institute, Boston, Massachusetts 021154

Received 2 February 1999/Returned for modification 14 June 1999/Accepted 24 June 1999

On the basis of biochemical, phenotypic, and 16S rRNA analyses, Helicobacter canis was isolated from Bengal cats with and without chronic diarrhea. Because the cats were coinfected with other potential pathogens, including Campylobacter helveticus, and because H. canis was isolated from nondiarrheic cats, the causal role of H. canis in producing the diarrhea could not be proven. Histologically, the colons of the four affected cats were characterized by mild to moderate neutrophilic, plasmacytic, and histocytic infiltrates in the lamina propria. Rare crypt abscesses were also noted for three cats but were a more prominent feature of the colonic lesions noted for the fourth cat. This is the first observation of H. canis in cats and raises the possibility that H. canis, like H. hepaticus and H. bilis in mice, can cause inflammation of the colon, particularly in hosts with immune dysregulation. Further studies are needed to determine the importance of H. canis as a primary enteric pathogen in cats and the role of cats in the possible zoonotic spread of H. canis to humans.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave., Building 16, Room 825C, Cambridge, MA 02139. Phone: (617) 253-1757. Fax: (617) 258-5708. E-mail: jgfox{at}mit.edu.

Journal of Clinical Microbiology, October 1999, p. 3271-3275, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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