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Journal of Clinical Microbiology, October 1999, p. 3421-3422, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Natural History of Intestinal Microsporidiosis among Patients Infected with Human Immunodeficiency Virus

Kristin Dascomb,1 Rebecca Clark,1,* Judith Aberg,2 Joseph Pulvirenti,3 Ross G. Hewitt,4 Patricia Kissinger,1 and Elizabeth S. Didier5

LSU School of Medicine, Tulane School of Public Health and Tropical Medicine, New Orleans,1 and Tulane Regional Primate Center, Covington,5 Louisiana; San Francisco General Hospital, San Francisco, California2; Cook County Hospital, Chicago, Illinois3; and State University of New York, Buffalo, New York4

Received 15 March 1999/Returned for modification 29 April 1999/Accepted 24 June 1999

A chart review of 73 human immunodeficiency virus (HIV)-infected patients with enteric microsporidiosis was conducted to define the natural history of microsporidiosis. A substantial proportion of patients remained symptomatic after 6 months (54.8% with persistent diarrhea and 51.2% with weight loss). Predictors for persistent diarrhea included high HIV RNA viral load and no initiation of protease inhibitor therapy.

* Corresponding author. Mailing address: Infectious Diseases, HIV Division, Medical Center of Louisiana at New Orleans, 136 South Roman St., New Orleans, LA 70112. Phone: (504) 568-7049. Fax: (504) 568-4732. E-mail: rebeccac{at}mailhost.tcs.tulane.edu.

Journal of Clinical Microbiology, October 1999, p. 3421-3422, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.