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Journal of Clinical Microbiology, October 1999, p. 3423-3424, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Intravenous Immunoglobulin Therapy: Confounding Effects on Serological Screening for Toxoplasmosis during Pregnancy

Hervé Pelloux,1,* Hélène Fricker-Hidalgo,1 Gilbert Brochier,2 Andrée Goullier-Fleuret,1 and Pierre Ambroise-Thomas1

Service de Parasitologie-Mycologie, CHU A Michallon, 38043 Grenoble Cedex,1 and Etablissement de Transfusion Sanguine Isère-Savoie, 502 fbg Maché, 73001 Chambéry Cedex,2 France

Received 27 January 1999/Returned for modification 26 April 1999/Accepted 24 June 1999

The serological diagnosis of toxoplasmic infection during pregnancy is intended to prevent congenital infection of the fetus. However, in the context of recurrent pregnancy loss intravenous immunoglobulin therapy can create a biological trap for the interpretation of serological results, with potentially serious consequences for the outcome of the pregnancy.


* Corresponding author. Mailing address: Service de Parasitologie-Mycologie, CHU A Michallon, BP 217, 38043 Grenoble Cedex, France. Phone: 33 4 76 76 54 90. Fax: 33 4 76 76 56 60. E-mail: Herve.Pelloux{at}ujf-grenoble.fr.


Journal of Clinical Microbiology, October 1999, p. 3423-3424, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.