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Journal of Clinical Microbiology, November 1999, p. 3718-3721, Vol. 37, No. 11
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Effects of OspA Vaccination on Lyme Disease Serologic Testing

Maria E. Aguero-Rosenfeld,1,* Janet Roberge,2 Carol A. Carbonaro,2 John Nowakowski,3 Robert B. Nadelman,3 and Gary P. Wormser3

Department of Pathology,1 and Division of Infectious Diseases, Department of Medicine,3 New York Medical College, and Westchester Medical Center,2 Valhalla, New York 10595

Received 7 May 1999/Returned for modification 15 July 1999/Accepted 11 August 1999

This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who developed early Lyme disease despite vaccination.

* Corresponding author. Mailing address: Clinical Laboratories, Room 1J-11a, Westchester Medical Center, Valhalla, NY 10595. Phone: (914) 493-7389. Fax: (914) 493-5742. E-mail: maria_aguero-rosenfeld{at}nymc.edu.

Journal of Clinical Microbiology, November 1999, p. 3718-3721, Vol. 37, No. 11
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1999 by the American Society for Microbiology. All rights reserved.