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Journal of Clinical Microbiology, November 1999, p. 3751-3755, Vol. 37, No. 11
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Fatal Case of Trichoderma harzianum Infection in a Renal Transplant Recipient

Josep Guarro,1,* María Isabel Antolín-Ayala,2 Josepa Gené,1 Jesús Gutiérrez-Calzada,2 Carlos Nieves-Díez,3 and Montserrat Ortoneda1

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, 43201 Reus,1 and Servicio de Microbiología2 and Servicio de Anatomía Patológica,3 Hospital de León, 28002 León, Spain

Received 19 April 1999/Returned for modification 22 June 1999/Accepted 18 August 1999

We describe the second known case of human infection by Trichoderma harzianum. A disseminated fungal infection was detected in the postmortem examination of a renal transplant recipient and confirmed in culture. The only other reported infection by this fungus caused peritonitis in a diabetic patient. The in vitro antifungal susceptibilities of the clinical strain and three other strains of Trichoderma species to six antifungal drugs are provided. This case illustrates the widening spectrum of opportunistic Trichoderma spp. in immunocompromised patients and emphasizes the problems in diagnosing invasive fungal diseases.

* Corresponding author. Mailing address: Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Tarragona, Spain. Phone: 34 977759359. Fax: 34 977759322. E-mail: umb{at}fmcs.urv.es.

Journal of Clinical Microbiology, November 1999, p. 3751-3755, Vol. 37, No. 11
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.