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Journal of Clinical Microbiology, December 1999, p. 4034-4038, Vol. 37, No. 12
Department of Ophthalmology,
Received 26 April 1999/Returned for modification 4 June
1999/Accepted 24 August 1999
We describe the clinical and laboratory features of a 55-year-old
human immunodeficiency virus-negative female patient who presented with
bilateral intraocular inflammatory disease (neuroretinitis type) and
behavioral changes caused by a Bartonella grahamii
infection. Diagnosis was based on the PCR analysis of DNA extracted
from the intraocular fluids. DNA analysis of the PCR product revealed a
100% identity with the 16S rRNA gene sequence of B. grahamii. The patient was successfully treated with doxycycline
(200 mg/day) and rifampin (600 mg/day) for 4 weeks. This is the first
report that demonstrates the presence of a Bartonella
species in the intraocular fluids of a nonimmunocompromised patient and
that indicates that B. grahamii is pathogenic for humans.
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Demonstration of Bartonella grahamii DNA
in Ocular Fluids of a Patient with Neuroretinitis
*
Corresponding author. Mailing address: Department of
Ophthalmology, F. C. Donders Institute, Academic Hospital Utrecht,
P.O. Box 85 500, 3508 GA Utrecht, The Netherlands. Phone: (30) 2507880. Fax: (30) 250 54 17. E-mail: fkerkh{at}oogheel.azu.nl.
Journal of Clinical Microbiology, December 1999, p. 4034-4038, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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