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Journal of Clinical Microbiology, December 1999, p. 4039-4041, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Genetic Relatedness among Nontypeable Pneumococci Implicated in Sporadic Cases of Conjunctivitis

Jason H. Barker,1 Daniel M. Musher,1,2,* Ronald Silberman,3 Hoang M. Phan,2 and David A. Watson4

Department of Medicine, Baylor College of Medicine,1 and Infectious Disease Laboratories, Veterans Affairs Medical Center,2 Houston, Texas; Department of Pathology, Louisiana State University Medical Center in Shreveport, Shreveport, Louisiana3; and Information Dynamics, Inc., Washington, D.C.4

Received 17 May 1999/Returned for modification 21 June 1999/Accepted 25 August 1999

Nontypeable Streptococcus pneumoniae is a common cause of epidemic conjunctivitis. A previous molecular fingerprinting study identified a clone of nontypeable pneumococcus that was responsible for a recent outbreak of conjunctivitis. In the present study, we examined the extent to which pneumococci that cause sporadic cases of conjunctivitis are related to this epidemic strain. Using arbitrarily primed BOX-PCR, we have determined that, of 10 nontypeable pneumococci causing sporadic conjunctivitis, 5 were clonal and closely related to a previous outbreak strain, whereas 5 others were genetically diverse.

* Corresponding author. Mailing address: Department of Veterans Affairs Medical Center, 2002 Holcombe Blvd., Infectious Disease Section (111G), Room 4b-370, Houston, TX 77030. Phone: (713) 794-7384. Fax: (713) 794-7045. E-mail: daniel.musher{at}med.va.gov.

Journal of Clinical Microbiology, December 1999, p. 4039-4041, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.