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Journal of Clinical Microbiology, December 1999, p. 4170-4173, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mycotic Keratitis Due to Curvularia senegalensis and In Vitro Antifungal Susceptibilities of Curvularia spp.

Josep Guarro,1,* Tiyomi Akiti,2 Roberto Almada- Horta,3 L. A. Morizot Leite-Filho,4 Josepa Gené,1 Sueli Ferreira-Gomes,3 Carme Aguilar,1 and Montserrat Ortoneda1

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, 43201 Reus, Spain,1 and Laboratorio de Micologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro,2 Laboratorio Almada Horta,3 and Instituto Benjamin Constant,4 Rio de Janeiro, Brazil

Received 7 June 1999/Returned for modification 10 July 1999/Accepted 18 August 1999

A case of mycotic keratitis due to Curvularia senegalensis is reported. This case represents the third known reported infection caused by this rare species. Fungal hyphae were detected in corneal scrapings, and repeated cultures were positive for this fungi. The patient was presumed cured after a corneal transplant and treatment with itraconazole, but the infection recurred and the patient is waiting for a keratoplasty. The in vitro antifungal susceptibilities of the case strain and another 24 strains belonging to seven species of Curvularia were tested for six antifungal agents. With the exception of flucytosine, and occasionally fluconazole, the other drugs assayed (amphotericin B, miconazole, itraconazole, and ketoconazole) were highly effective in vitro.

* Corresponding author. Mailing address: Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Tarragona, Spain. Phone: 34 977759359. Fax: 34 977759322. E-mail: umb{at}fmcs.urv.es.

Journal of Clinical Microbiology, December 1999, p. 4170-4173, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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