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Journal of Clinical Microbiology, February 1999, p. 430-432, Vol. 37, No. 2
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Performance Characteristics of an Enzyme-Linked Immunosorbent Assay for Determining Salivary Immunoglobulin G Response to Helicobacter pylori

R. De Pascalis,1,* M. Del Pezzo,1 G. Nardone,2 G. Budillon,2 and A. Lavitola1

Cattedra di Microbiologia Clinica, Dipartimento di Biologia e Patologia Cellulare e Molecolare,1 and Cattedra di Gastroenterologia, Dipartimento di Patologia Sistematica,2 Universita' degli Studi di Napoli "Federico II," 80131 Naples, Italy

Received 5 August 1998/Returned for modification 15 September 1998/Accepted 2 November 1998

We evaluated the salivary immunoglobulin G (IgG) immune response to Helicobacter pylori in 70 subjects by enzyme-linked immunosorbent assay (ELISA). Subjects with a positive H. pylori culture showed significantly higher titers of antibodies than subjects with no detectable H. pylori: the overall sensitivity and specificity of the test were 84 and 90%, respectively. The detection of salivary anti-H. pylori IgG antibodies may be considered as an alternative to serum IgG detection for ease of sample collection or when blood samples are not available in screening of patients with dyspepsia.

* Corresponding author. Present address: Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. 5B38, 9000 Rockville Pike, Bethesda, MD 20892. Phone: (301) 496-0419. Fax: (301) 402-0711 or (301) 480-2002. E-mail: pascalir{at}mail.nih.gov.

Journal of Clinical Microbiology, February 1999, p. 430-432, Vol. 37, No. 2
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.