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Journal of Clinical Microbiology, March 1999, p. 838-840, Vol. 37, No. 3
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Cryptococcus neoformans var. grubii: Separate Varietal Status for Cryptococcus neoformans Serotype A Isolates

Sarah P. Franzot,1 Ira F. Salkin,2 and Arturo Casadevall3,*

Department of Pharmacology, Cornell University Medical College, New York,1 Wadsworth Center, New York State Department of Health, Albany,2 and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx,3 New York

Received 20 October 1998/Returned for modification 8 December 1998/Accepted 17 December 1998

Cryptococcus neoformans var. neoformans presently includes isolates which have been determined by the immunologic reactivity of their capsular polysaccharides to be serotype A and those which have been determined to be serotype D. However, recent analyses of the URA5 sequences and DNA fingerprinting patterns suggest significant genetic differences between the two serotypes. Therefore, we propose to recognize these genotypic distinctions, as well as previously reported phenotypic differences, by restricting C. neoformans var. neoformans to isolates which are serotype D and describing a new variety, C. neoformans var. grubii, for serotype A isolates.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, 1300 Morris Park Ave., Golding Bldg., Room 701, Bronx, NY 10461. Phone: (718) 430-4259. Fax: (718) 430-8701. E-mail: casadeva{at}aecom.yu.edu.

Journal of Clinical Microbiology, March 1999, p. 838-840, Vol. 37, No. 3
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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