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Journal of Clinical Microbiology, March 1999, p. 864-866, Vol. 37, No. 3
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Evaluation of the Fungitest Kit by Using Strains from Human Immunodeficiency Virus-Infected Patients: Study of Azole Drug Susceptibility

F. Witthuhn,1,* D. Toubas,1 I. Béguinot,2 D. Aubert,1 C. Rouger,2 G. Remy,2 and J. M. Pinon1

Laboratoire de Parasitologie---Mycologie, Equipe 4 INSERM U 314, EA 2070, IFR 53,1 and Service des Maladies Infectieuses,2 Centre Hospitalier Universitaire de Reims, France

Received 4 June 1998/Returned for modification 30 September 1998/Accepted 12 December 1998

One hundred eighteen Candida clinical isolates from human immunodeficiency virus-infected patients were tested for their susceptibilities to fluconazole and itraconazole by Fungitest and the National Committee for Clinical Laboratory Standards MIC method. Fungitest results depended on both yeast species and antifungal agents. This test is able to detect sensitive strains (97% agreement with results of the MIC method in tests with fluconazole and 84% agreement in tests with itraconazole) but has a poor capacity to detect resistant strains (26% agreement in tests with fluconazole and 5% agreement in tests with itraconazole).

* Corresponding author. Mailing address: Laboratoire de Parasitologie---Mycologie, Hôpital Maison Blanche, 45, rue Cognacq-Jay, 51092 Reims Cedex, France. Phone: (33) 3 26 78 42 20. Fax: (33) 3 26 78 73 28. E-mail: jmpinon{at}chu-reims.fr.

Journal of Clinical Microbiology, March 1999, p. 864-866, Vol. 37, No. 3
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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