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Journal of Clinical Microbiology, April 1999, p. 1165-1167, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunohistochemical Detection of JC Virus in Nontumorous Renal Tissue of a Patient with Renal Cancer but without Progressive Multifocal Leukoencephalopathy

Naoto Aoki,1,* Tadaichi Kitamura,2 Takashi Tominaga,3 Nobutaka Fukumori,1 Yosimitsu Sakamoto,1 Kenzo Kato,4 and Mayumi Mori5

Division of Pathology, Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Hyakunincho, Shinjukuku, Tokyo 169,1 Department of Urology, Branch Hospital, Faculty of Medicine, The University of Tokyo, Mejirodai, Bunkyo-ku, Tokyo 112,2 Department of Urology, Mitui Memorial Hospital, Izumicho, Kanda, Tokyo 101,3 Department of Virology II, National Institute of Health, Toyama, Shinjukuku, Tokyo 162,4 and Department of Hematology, Tokyo Metropolitan Institute of Gerontology, Sakaecho, Itabashiku, Tokyo 173,5 Japan

Received 2 July 1998/Returned for modification 9 November 1998/Accepted 21 December 1998

We performed immunohistochemical staining on the nontumorous renal tissue of 45 patients with renal cancer but without progressive multifocal encephalopathy using JCV-specific antibody. For one patient we found positive staining of the nuclei of the renal collecting ducts. Immunoelectron microscopic examination of the positive cell nuclei revealed electron-dense polyomavirus-like particles.

* Corresponding author. Mailing address: Division of Pathology, Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1 Hyakunincho, Shinjukuku, Tokyo 169, Japan. Phone: 81-3-3363-3231, ext. 5700. Fax: 81-3-3368-4060. E-mail: naoto{at}tokyo-eiken.go.jp.

Journal of Clinical Microbiology, April 1999, p. 1165-1167, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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