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Journal of Clinical Microbiology, April 1999, p. 1186-1189, Vol. 37, No. 4
Departments of Medical
Microbiology,1 Internal
Medicine,2 and
Neurology,3 University Hospital
Nijmegen, Nijmegen, The Netherlands
Received 31 August 1998/Returned for modification 15 October
1998/Accepted 30 December 1998
The performance of antibody detection, antigen detection, and
Aspergillus genus-specific PCR for diagnosing
Aspergillus meningitis was investigated with 26 cerebrospinal fluid (CSF) samples obtained from a single patient with
proven infection caused by Aspergillus fumigatus.
Immunoglobulin G antibodies directed against Aspergillus were not detected by enzyme-linked immunosorbent assay in CSF or serum.
The antigen galactomannan was detected in the CSF 45 days before a
culture became positive, and Aspergillus DNA was detected 4 days prior to culture. Decline of the galactomannan antigen titer in
the CSF during treatment with intravenous and intraventricular
amphotericin B and intravenous voriconazole corresponded with the
clinical response to treatment.
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Aspergillus Meningitis: Diagnosis by
Non-Culture-Based Microbiological Methods and Management

*
Corresponding author. Mailing address: Department of
Medical Microbiology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax:
31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.
Present address: Department of Internal Medicine, Onze Lieve Vrouwe
Gasthuis, Amsterdam, The Netherlands.
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