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Journal of Clinical Microbiology, May 1999, p. 1265-1268, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Molecular Epidemiology of Tuberculosis in Malaysia

Jeremy W. Dale,1,* Rohana Mat Nor,2,dagger Soshila Ramayah,3 Thean Hock Tang,2 and Zainul F. Zainuddin2

University of Surrey, Guildford, Surrey, United Kingdom,1 and Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian,2 and Institute for Respiratory Medicine, Kuala Lumpur,3 Malaysia

Received 20 October 1998/Returned for modification 17 December 1998/Accepted 25 January 1999

Molecular typing with IS6110 was applied to Mycobacterium tuberculosis isolates from all parts of Malaysia. The degree of clustering increased with patient age, suggesting that reactivation may contribute to clustering. Identical banding patterns were also obtained for isolates from widely separate regions. Therefore, the use of clustering as a measure of recent transmission must be treated with caution. Strains related to the Beijing family were common in Peninsular Malaysia but were less common in Sabah and Sarawak, while a distinct group of strains comprised nearly 40% of isolates from East Malaysia but such strains were rare in Peninsular Malaysia. Single-copy strains, common in South and Southeastern Asia, constituted nearly 20% of isolates from the peninsula but were virtually absent in East Malaysia. The marked geographical difference in the prevailing strains indicates not only a restricted dissemination of M. tuberculosis but also a considerable degree of stability in the banding patterns.

* Corresponding author. Mailing address: School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK. Phone: 44 1483 300800. Fax: 44 1483 300374. E-mail: j.dale{at}surrey.ac.uk.

dagger Present address: Institut Teknologi, MARA, Nilai, Negeri Sembilan, Malaysia.

Journal of Clinical Microbiology, May 1999, p. 1265-1268, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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