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Journal of Clinical Microbiology, May 1999, p. 1302-1305, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Cryptosporidium "Mouse" Genotype Is Conserved across Geographic Areas

Una M. Morgan,1,* Anthony P. Sturdee,2 Grant Singleton,3 M. Soledad Gomez,4 Mercedes Gracenea,4 Jordi Torres,4 Steven G. Hamilton,5 D. P. Woodside,5 and R. C. Andrew Thompson1

World Health Organisation Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and State Agricultural Biotechnology Centre, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia, 6150,1 Commonwealth Scientific and Industrial Research Organisation, Division of Wildlife and Ecology, Lyneham, Australian Capital Territory, 2602,3 and Australian Conservation Training Institute, Taronga Zoo, Mosman, New South Wales, 2088,5 Australia; School of Natural and Environmental Sciences, Coventry University, Coventry CV1 5FB, United Kingdom2;Laboratori de Parasitologia, Facultat de Farmacia, Universitat de Barcelona, 08028, Barcelona, Spain4

Received 9 November 1998/Accepted 26 January 1999

A 298-bp region of the Cryptosporidium parvum 18S rRNA gene and a 390-bp region of the acetyl coenzyme A synthetase gene were sequenced for a range of Cryptosporidium isolates from wild house mice (Mus domesticus), a bat (Myotus adversus), and cattle from different geographical areas. Previous research has identified a distinct genotype, referred to as the "mouse"-derived Cryptosporidium genotype, common to isolates from Australian mice. Comparison of a wider range of Australian mouse isolates with United Kingdom and Spanish isolates from mice and cattle and also an Australian bat-derived Cryptosporidium isolate revealed that the "mouse" genotype is conserved across geographic areas. Mice are also susceptible to infection with the "cattle" Cryptosporidium genotype, which has important implications for their role as reservoirs of infection for humans and domestic animals.

* Corresponding author. Mailing address: World Health Organisation Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and State Agricultural Biotechnology Centre, Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA, 6150, Australia. Phone: (08) 9360 2457. Fax: (08) 9310 4144. E-mail: morgan{at}numbat.murdoch.edu.au.

Journal of Clinical Microbiology, May 1999, p. 1302-1305, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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