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Journal of Clinical Microbiology, May 1999, p. 1319-1323, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Recurrent "Flexispira rappini" Bacteremia in an Adult Patient Undergoing Hemodialysis: Case Report

P. Sorlin,1 P. Vandamme,2 J. Nortier,3 B. Hoste,2 C. Rossi,4 S. Pavlof,1 and M. J. Struelens1,*

Services de Microbiologie,1 de Néphrologie,3 et de Maladies Infectieuses,4 Université Libre de Bruxelles-Erasme Hospital, B-1070 Brussels, and Laboratorium voor Microbiologie, University of Ghent, B-9000 Ghent,2 Belgium

Received 8 September 1998/Returned for modification 17 October 1998/Accepted 25 January 1999

A blood culture from a 65-year-old febrile man undergoing hemodialysis revealed, 5 days after inoculation, an unusual gram-negative fusiform rod with darting motility. During another episode of fever 21 days later, this Campylobacter-like organism was again recovered from three blood cultures and subcultured under an H2-enriched microaerobic atmosphere. The organism was catalase negative and oxidase positive and hydrolyzed urea rapidly. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of whole-cell proteins was indistinguishable from that of "Flexispira rappini" LMG 8738 described by Archer et al. in 1988 (J. R. Archer, S. Romero, A. E. Ritchier, M. E. Hamacher, B. M. Steiner, J. H. Bryner, and R. F. Schell, J. Clin. Microbiol. 26:101-105, 1988). The analysis of the 16S ribosomal DNA sequence revealed a similarity of 99.3% between the two strains. The patient recovered completely after a 4-week course of meropenem therapy. This is the first reported case of a recurrent "F. rappini" bacteremia in an adult patient, which confirms that this organism may be an invasive pathogen in immunocompromised patients, like other newly described Helicobacter species.

* Corresponding author. Mailing address: Microbiology Department, Université Libre de Bruxelles-Hôpital Erasme, Route de Lennik 808, 1070 Bruxelles, Belgium. Phone: 32 2 555 34 84. Fax: 32 2 555 64 59. E-mail: marc.struelens{at}ulb.ac.be.

Journal of Clinical Microbiology, May 1999, p. 1319-1323, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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