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Journal of Clinical Microbiology, May 1999, p. 1431-1435, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Comparison of Cytomegalovirus Loads in Plasma and Leukocytes of Patients with Cytomegalovirus Retinitis

Douglas A. Jabs,1,2,* Michael Forman,3 Cheryl Enger,4 and J. Brooks Jackson3,dagger for The Cytomegalovirus Retinitis and Viral Resistance Study Group

Departments of Ophthalmology,1 Medicine,2 Pathology,3 and Oncology,4 The Johns Hopkins University School of Medicine, Baltimore, Maryland

Received 3 November 1998/Returned for modification 21 December 1998/Accepted 28 January 1999

Cytomegalovirus (CMV) DNA loads in paired leukocyte and plasma samples from 199 patient visits by 66 patients with CMV retinitis were determined. Leukocyte CMV load determinations had a greater range of values (mean, 24,587 copies/106 leukocytes; maximum, 539,000) than did plasma CMV load determinations (mean, 10,302 copies/ml; maximum, 386,000), and leukocyte viral loads were detectable in a greater proportion of patients at the time of diagnosis of CMV retinitis prior to initiation of anti-CMV therapy (82%) than were plasma viral loads (64%) (P = 0.0078). Agreement with CMV blood cultures was slightly better for plasma (kappa  = 0.68) than for leukocytes (kappa  = 0.53), due to a greater proportion of patients with detectable viral loads in leukocytes having negative blood cultures.

* Corresponding author. Mailing address: 550 North Broadway, Suite 700, Baltimore, MD 21205. Phone: (410) 955-1966. Fax: (410) 955-0629. E-mail: dajabs{at}welchlink.welch.jhu.edu.

dagger Other group members include John Bartlett, Stephen G. Bolton, James P. Dunn, Susan LaSalvia, Laura G. Neisser, Earline Nanan, Richard D. Semba, John H. Kempen, Quan D. Nguyen, Shirley Quaskey, Judy Southall, Joseph B. Margolick, Elvia Ramirez, Matthew D. Davis, Larry Hubbard, Judy Brickbauer, Linda Kastorff, and Tamieca Hamlin.

Journal of Clinical Microbiology, May 1999, p. 1431-1435, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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