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Journal of Clinical Microbiology, May 1999, p. 1567-1569, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Second Generation of the Automated Cobas Amplicor HCV Assay Improves Sensitivity of Hepatitis C Virus RNA Detection and Yields Results That Are More Clinically Relevant

Alain Doglio,1,* Catherine Laffont,1 François X. Caroli-Bosc,2 Pascale Rochet,1 and J.-Claude Lefebvre1

Laboratoire de Virologie, Faculté de Médecine, 06107 Nice,1 and Service d'Hépato-Gastroentérologie, Hôpital de l'Archet II, 06202 Nice,2 France

Received 19 October 1998/Returned for modification 6 January 1999/Accepted 29 January 1999

The first and second generations of the Cobas Amplicor HCV assay were compared among patients at risk of hepatitis C virus (HCV) infection. The second-generation test was found to be of greater sensitivity and of good specificity among clinical specimens containing HCV RNA of different genotypes. Finally, this new test is shown to predict the outcome of interferon therapy better.

* Corresponding author. Mailing address: Laboratoire de Virologie, Faculté de Médecine, Avenue de Valombrose, 06107 Nice Cedex 2, France. Phone: (33)04.93.37.76.78. Fax: (33)04.93.81.54.84. E-mail: doglio{at}unice.fr.

Journal of Clinical Microbiology, May 1999, p. 1567-1569, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.