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Journal of Clinical Microbiology, May 1999, p. 1595-1597, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Comparison of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Mutations in HIV-1 Genomes Detected in Plasma and in Peripheral Blood Mononuclear Cells from Patients Receiving Combination Drug Therapy

Nathalie Koch,1 Nouara Yahi,1 Franck Ariasi,2 Jacques Fantini,2 and Catherine Tamalet1,*

Laboratoire de Virologie, CHRU La Timone, 13005 Marseille,1 and Laboratoire de Biochimie et Biologie de la Nutrition, CNRS ESA 6033, Faculté des Sciences St. Jérôme, 13013 Marseille,2 France

Received 4 May 1998/Returned for modification 17 August 1998/Accepted 1 February 1999

Detections of mutations in the protease gene of human immunodeficiency virus type 1 in plasma and peripheral blood mononuclear cells (PBMC) were sought in two matched populations of 23 individuals receiving combination drug therapy with or without protease inhibitors. In the control group (23 patients not receiving protease inhibitors), no primary resistance mutations were found. In contrast, primary resistance mutations (especially at codons M46, V82, and L90) were found in 16 of 23 patients (70%) treated with protease inhibitors. In 30% of the cases, these mutations were detected in plasma but not in PBMC.

* Corresponding author. Mailing address: Laboratoire de Virologie, CHRU La Timone, 13005 Marseille, France. Phone: 33-491-385-522. Fax: 33-491-779-266. E-mail: ctamalet{at}ap-hm.fr.

Journal of Clinical Microbiology, May 1999, p. 1595-1597, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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