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Journal of Clinical Microbiology, May 1999, p. 1606-1609, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Invasive Aspergillosis Caused by Aspergillus ustus: Case Report and Review

Paul E. Verweij,1,* Marjolein F. Q. van den Bergh,1 Peter M. Rath,2 Ben E. de Pauw,3 Andreas Voss,1 and Jacques F. G. M. Meis1

Departments of Medical Microbiology1 and Hematology,3 University Hospital Nijmegen, Nijmegen, The Netherlands, and Institut für Medizinische Mikrobiologie, Universität-GH Essen, Essen, Germany2

Received 21 September 1998/Returned for modification 21 October 1998/Accepted 26 January 1999

A case of invasive pulmonary aspergillosis in an allogeneic bone marrow transplant recipient caused by Aspergillus ustus is presented. A. ustus was also recovered from the hospital environment, which may indicate that the infection was nosocomially acquired. A literature review revealed seven cases of invasive infections caused by A. ustus, and three of these were primarily cutaneous infections. In vitro susceptibility testing of 12 A. ustus isolates showed that amphotericin B and terbinafine had fungicidal activity and that itraconazole and voriconazole had fungistatic activity.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.

Journal of Clinical Microbiology, May 1999, p. 1606-1609, Vol. 37, No. 5
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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