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Journal of Clinical Microbiology, June 1999, p. 1758-1763, Vol. 37, No. 6
Division of Infectious Disease,
Received 4 November 1998/Returned for modification 16 January
1999/Accepted 24 February 1999
Two hundred ninety isolates of Escherichia coli were
investigated for the production of extended-spectrum
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Survey of Extended-Spectrum
-Lactamases in
Clinical Isolates of Escherichia coli and Klebsiella
pneumoniae: Prevalence of TEM-52 in Korea
-lactamases
(ESBLs). Fourteen (4.8%) of the 290 strains were found to produce
ESBLs. Each of the 14 strains produced one or two ESBLs, as follows: 10 strains produced TEM-52, 1 strain produced SHV-2a, 1 strain produced
SHV-12, 1 strain produced a CMY-1-like enzyme, and 1 strain expressed
SHV-2a and a CMY-1-like enzyme. Another two strains for which the MICs
of ceftazidime and cefoxitin were high, were probable AmpC enzyme
hyperproducers. Because of the high prevalence of TEM-52 in E. coli isolates, we further investigated the TEM-type ESBLs
produced by Klebsiella pneumoniae in order to observe the distribution of TEM-52 enzymes among Enterobacteriaceae in
Korea. All TEM enzymes produced by 12 strains of K. pneumoniae were identified as TEM-52. To evaluate the genetic
relatedness among the organisms, ribotyping of TEM-52-producing
E. coli and K. pneumoniae was performed. The
ribotyping profiles of the organisms showed similar but clearly different patterns. In conclusion, TEM-52 is the most prevalent TEM-type ESBL in Korea.
*
Corresponding author. Mailing address: Division of
Infectious Disease, Department of Internal Medicine, College of
Medicine, University of Dankook, San 29, Anseo-dong, Chonan, Chungnam,
330-715, Korea. Phone: 82-417-550-3918. Fax: 82-417-556-3256. E-mail:
paihj{at}unitel.co.kr.
Journal of Clinical Microbiology, June 1999, p. 1758-1763, Vol. 37, No. 6
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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