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Journal of Clinical Microbiology, June 1999, p. 1758-1763, Vol. 37, No. 6
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Survey of Extended-Spectrum beta -Lactamases in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae: Prevalence of TEM-52 in Korea

Hyunjoo Pai,1,* Sen Lyu,1 Ji Hyang Lee,1 Jungmin Kim,2 Youngmi Kwon,2 Jong-Won Kim,3 and Kang Won Choe4

Division of Infectious Disease, Department of Internal Medicine,1 and Department of Microbiology,2 College of Medicine, University of Dankook, Chonan, and Department of Clinical Pathology, Sungkyunkwan University College of Medicine,3 and Department of Internal Medicine, Seoul National University College of Medicine,4 Seoul, Korea

Received 4 November 1998/Returned for modification 16 January 1999/Accepted 24 February 1999

Two hundred ninety isolates of Escherichia coli were investigated for the production of extended-spectrum beta -lactamases (ESBLs). Fourteen (4.8%) of the 290 strains were found to produce ESBLs. Each of the 14 strains produced one or two ESBLs, as follows: 10 strains produced TEM-52, 1 strain produced SHV-2a, 1 strain produced SHV-12, 1 strain produced a CMY-1-like enzyme, and 1 strain expressed SHV-2a and a CMY-1-like enzyme. Another two strains for which the MICs of ceftazidime and cefoxitin were high, were probable AmpC enzyme hyperproducers. Because of the high prevalence of TEM-52 in E. coli isolates, we further investigated the TEM-type ESBLs produced by Klebsiella pneumoniae in order to observe the distribution of TEM-52 enzymes among Enterobacteriaceae in Korea. All TEM enzymes produced by 12 strains of K. pneumoniae were identified as TEM-52. To evaluate the genetic relatedness among the organisms, ribotyping of TEM-52-producing E. coli and K. pneumoniae was performed. The ribotyping profiles of the organisms showed similar but clearly different patterns. In conclusion, TEM-52 is the most prevalent TEM-type ESBL in Korea.

* Corresponding author. Mailing address: Division of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Dankook, San 29, Anseo-dong, Chonan, Chungnam, 330-715, Korea. Phone: 82-417-550-3918. Fax: 82-417-556-3256. E-mail: paihj{at}unitel.co.kr.

Journal of Clinical Microbiology, June 1999, p. 1758-1763, Vol. 37, No. 6
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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