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Journal of Clinical Microbiology, June 1999, p. 2007-2009, Vol. 37, No. 6
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunochromatography Test for Rapid Diagnosis of Adenovirus Respiratory Tract Infections: Comparison with Virus Isolation in Tissue Culture

Hiroyuki Tsutsumi,1,* Kazunobu Ouchi,2 Masaya Ohsaki,1 Tatsuru Yamanaka,3 Yoshinori Kuniya,4 Yoshinao Takeuchi,5 Chiaki Nakai,5 Hidenori Meguro,6 and Shunzo Chiba1

Department of Pediatrics, Sapporo Medical University School of Medicine,1 Yamanaka Tatsuru Pediatric Clinic,3 and Department of Pediatrics, NTT Sapporo Hospital,4 Sapporo, Department of Pediatrics, Saiseikai Shimonoseki General Hospital, Shimonoseki,2 Department of Pediatrics, Kawasaki Municipal Hospital, Kawasaki,5 and Department of Pediatrics, Teikyo University Ichihara Hospital, Ichihara,6 Japan

Received 14 December 1998/Returned for modification 11 January 1999/Accepted 8 March 1999

The sensitivity and the specificity of a new commercial rapid 10-min adenovirus antigen immunochromatography (IC) test were determined by comparison with the sensitivity and specificity of virus isolation. Of 169 pharyngeal swabs from children with suspected adenovirus respiratory tract infections, 95 (56%) were culture positive for adenovirus. The IC test was sensitive (detecting 69 of these 95 infections [72.6%]) and completely specific (identifying 74 of 74 specimens [100%]) when it was compared with cell culture. The test detected adenovirus serotypes 1, 2, 3, 5, and 7 with almost equal sensitivities. This test is not only rapid and easy to perform but also sensitive and specific for adenovirus respiratory tract infections. The test is sufficiently rapid to be used at the bedside or in an outpatient clinic, with the result being available during a patient's first examination.

* Corresponding author. Mailing address: Department of Pediatrics, Sapporo Medical University School of Medicine, Chuoku S-1, W-16, Sapporo, 060-8543 Japan. Phone: 81-11-611-2111. Fax: 81-11-611-0352. E-mail: tsutsumi{at}sapmed.ac.jp.

Journal of Clinical Microbiology, June 1999, p. 2007-2009, Vol. 37, No. 6
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Fujimoto, T., Okafuji, T., Okafuji, T., Ito, M., Nukuzuma, S., Chikahira, M., Nishio, O. (2004). Evaluation of a Bedside Immunochromatographic Test for Detection of Adenovirus in Respiratory Samples, by Comparison to Virus Isolation, PCR, and Real-Time PCR. J. Clin. Microbiol. 42: 5489-5492 [Abstract] [Full Text]  
  • Gavin, P. J., Katz, B. Z. (2002). Intravenous Ribavirin Treatment for Severe Adenovirus Disease in Immunocompromised Children. Pediatrics 110: e9-9 [Abstract] [Full Text]  


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