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Journal of Clinical Microbiology, July 1999, p. 2165-2169, Vol. 37, No. 7
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Most Enterobacter aerogenes Strains in France Belong to a Prevalent Clone

Claude Bosi, Anne Davin-Regli,* Charleric Bornet, Monique Mallea, Jean-Marie Pages, and Claude Bollet

Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 96-06 INSERM, Faculté de Médecine, Université de la Mediterranée, 13385 Marseille Cedex 05, France

Received 12 October 1998/Returned for modification 5 January 1999/Accepted 25 March 1999

The aim of this study was to determine the distribution in France of the Enterobacter aerogenes prevalent clone isolated in the hospitals of the Marseille area (A. Davin-Regli, D. Monnet, P. Saux, C. Bosi, R. Charrel, A. Barthelemy, and C. Bollet, J. Clin. Microbiol. 34:1474-1480, 1996). A total of 123 E. aerogenes isolates were collected from 23 hospital laboratories and analyzed by random amplification of polymorphic DNA and enterobacterial repetitive intergenic consensus-PCR to determine their epidemiological relatedness. Molecular typing revealed that 21 of the 23 laboratories had isolated this prevalent clone harboring the plasmid encoding for extended-spectrum beta -lactamase of the TEM-24 type. Most isolates were susceptible only to imipenem and gentamicin. Their dissemination seems to be clonal and was probably the result of the general use of broad-spectrum cephalosporins and quinolones. Four isolates showed an alteration of their outer membrane proteins, causing decrease of susceptibility to third-generation cephalosporins and imipenem and leading to the critical situation of having no alternative therapeutic. The large dissemination of the E. aerogenes prevalent clone probably results from its good adaptation to the antibiotics administered in France and the hospital environment, particularly in intensive care units.

* Corresponding author. Mailing address: CJF 96-06 INSERM, Faculté de Médecine, 27 Blvd. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4-91-32-45-29. Fax: (33) 4-91-32-46-06. E-mail: cbollet{at}ap-hm.fr.

Journal of Clinical Microbiology, July 1999, p. 2165-2169, Vol. 37, No. 7
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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