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Journal of Clinical Microbiology, August 1999, p. 2699-2702, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Indigenous Disseminated Penicillium marneffei Infection in the State of Manipur, India: Report of Four Autochthonous Cases

P. Narendra Singh,1 K. Ranjana,2 Y. Indiver Singh,1 K. Priyokumar Singh,1 S. Surchandra Sharma,3 M. Kulachandra,2 Y. Nabakumar,3 A. Chakrabarti,4 A. A. Padhye,5,* L. Kaufman,5 and L. Ajello6

Departments of Medicine,1 Microbiology,2 and Pathology,3 J. N. Medical Hospital, Imphal, Manipur, and Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012,4 India, Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,5 and Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 303226

Received 1 March 1999/Returned for modification 30 March 1999/Accepted 1 May 1999

We describe four cases of disseminated infection caused by endemic Penicillium marneffei in human immunodeficiency virus (HIV)-infected patients from the Manipur state of India. The most common clinical features observed were fever, anorexia, weight loss, hepatosplenomegaly, and, more importantly, skin lesions resembling molluscum contagiosum. The diagnosis in each of the four cases was achieved by direct examination of smears, observance of intracellular yeast-like cells multiplying by fission in biopsied tissue from skin lesions, and isolation of the dimorphic P. marneffei in pure culture in each case. In one case, fluorescent antibody studies allowed specific diagnosis. This report documents a new area in which P. marneffei is endemic, located in eastern India, and describes the first occurrence in India of P. marneffei in HIV-infected patients as well as the extension of the areas of P. marneffei endemicity westward to the northeastern state of Manipur.

* Corresponding author. Mailing address: Mycotic Diseases Branch, Mail Stop G-11, Centers for Disease Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-3749. Fax: (404) 639-3546. E-mail: aap1{at}cdc.gov.

Journal of Clinical Microbiology, August 1999, p. 2699-2702, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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