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Journal of Clinical Microbiology, August 1999, p. 2717-2718, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Typing of Clinical Herpes Simplex Virus Type 1 and
Type 2 Isolates with Monoclonal Antibodies
Jan-Åke
Liljeqvist,*
Bo
Svennerholm, and
Tomas
Bergström
Department of Virology, University of
Göteborg, S-413 46 Göteborg, Sweden
Received 17 December 1998/Returned for modification 7 February
1999/Accepted 21 April 1999
The purpose of this study was to evaluate the performance of a
herpes simplex virus (HSV) type 1-specific anti-glycoprotein C-1
monoclonal antibody (MAb) and a type 2-specific anti-glycoprotein G-2
MAb for typing of 2,400 clinical HSV-1 isolates and 2,400 clinical
HSV-2 isolates, respectively, using an enzyme immunoassay. The
anti-HSV-1 MAb showed sensitivity and specificity of 100%, and the
anti-HSV-2 MAb showed a sensitivity of 99.46% and 100% specificity,
indicating that these MAbs are suitable for typing of clinical HSV isolates.
*
Corresponding author. Mailing address: Department of
Virology, University of Göteborg, Guldhedsgatan 10 B, S-413 46 Göteborg, Sweden. Phone: 46 31 3424657. Fax: 46 31 3424960. E-mail: jan-ake.liljeqvist{at}mednet.gu.se.
Journal of Clinical Microbiology, August 1999, p. 2717-2718, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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