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Journal of Clinical Microbiology, August 1999, p. 2726-2728, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Diagnostic Value of Anti-Hepatitis C Virus (HCV) Core Immunoglobulin M in Recurrence of HCV Infection after Orthotopic Liver Transplantationdagger

Carmela Casino,1 Daniela Lilli,1 Daniela Rivanera,1 Antonella Comanducci,1 Massimo Rossi,2 Giovanni Casciaro,2 Irene Pecorella,2 Dario Alfani,2,Dagger and Carlo Mancini1,*

Clinical Microbiology, I Chair, School of Medicine, University of Rome "La Sapienza,"1 and Transplantation Unit, Policlinico "Umberto I,"2 Rome, Italy

Received 21 January 1999/Returned for modification 29 March 1999/Accepted 19 April 1999

The significance of anti-hepatitis C virus (HCV) core immunoglobulin M (IgM) and its relationship with genotypes, alanine aminotransferase abnormality, and histological data were studied for 18 patients who had undergone orthotopic liver transplantation due to HCV-related end-stage disease. During follow-up, IgM response seemed to be associated with the recurrence of HCV infection but did not correlate with abnormal alanine aminotransferase levels and histological data. In addition, the results of this study indicated that the detection of HCV RNA is critical for diagnosis of reinfection in liver transplantation.

* Corresponding author. Mailing address: Institute of Microbiology, University of Rome "La Sapienza," P.le Aldo Moro, 5, 00185 Rome, Italy. Phone: 0039 06 49914609. Fax: 0039 06 49914641. E-mail: mancini{at}axrma.uniroma1.it.

dagger Dedicated to the memory of Dario Alfani.

Dagger Deceased.

Journal of Clinical Microbiology, August 1999, p. 2726-2728, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 1999 by the American Society for Microbiology. All rights reserved.