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Journal of Clinical Microbiology, September 1999, p. 3005-3009, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Cocirculation of Two Distinct Lineages of Equine Influenza Virus Subtype H3N8

L. Oxburgh1,* and B. Klingeborn2

Department of Veterinary Microbiology/Virology Section, Swedish University of Agricultural Sciences,1 and Department of Virology, National Veterinary Institute,2 Biomedical Center, S-751 23 Uppsala, Sweden

Received 14 October 1998/Returned for modification 8 March 1999/Accepted 12 May 1999

Direct amplification and sequencing of the hemagglutinin (HA) genes of equine influenza virus subtype H3N8 was undertaken in order to characterize strains of this virus circulating in Sweden. The majority of viruses from outbreaks during 1997 analyzed belonged to the American lineage of H3 equine influenza, and one strain was shown to belong to the European lineage. Furthermore, it was shown that recent American-lineage strains are mutated at amino acid position 190 of the HA during serial passage in embryonated hens' eggs. Host cell adaptation of these viruses thus takes place at antigenic region B of the HA.

* Corresponding author. Present address: Department of Cellular and Molecular Biology, Harvard University, 16 Divinity Ave., Cambridge, MA 02138. Phone: (617) 496-4989. Fax: (617) 496-6770. E-mail: Leif.Oxburgh{at}vmm.slu.se.

Journal of Clinical Microbiology, September 1999, p. 3005-3009, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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