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Journal of Clinical Microbiology, September 1999, p. 3022-3024, Vol. 37, No. 9
Unidade dos Retrovírus e
Infecções Associadas and Centro de Patogénese
Molecular, Faculdade de Farmácia da Universidade de Lisboa,
1649-019 Lisbon, Portugal
Received 25 January 1999/Returned for modification 20 March
1999/Accepted 18 May 1999
The rpoB gene mutations in a 69-bp region of the gene,
resulting in resistance to rifampin, were used to discriminate between Mycobacterium tuberculosis IS6110 fingerprint
subclusters. These subclusters exhibited identical IS6110
fragments or had one or two additional fragments. In the two major
subclusters all the analyzed strains have the same variant
rpoB allele but are different from each other, suggesting
the occurrence of independent outbreaks.
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Discrimination of Multidrug-Resistant
Mycobacterium tuberculosis IS6110 Fingerprint
Subclusters by rpoB Gene Mutation Analysis
*
Corresponding author. Mailing address: Centro de
Patogénese Molecular, Faculdade de Farmácia da Universidade
de Lisboa, Av. Forças Armadas, 1649-019 Lisbon, Portugal. Phone:
351-1-7946439. Fax: 351-1-7934212. E-mail:
isabel.portugal{at}ff.ul.pt.
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