This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sturm-Ramirez, K.
Right arrow Articles by Kanki, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sturm-Ramirez, K.
Right arrow Articles by Kanki, P. J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2000, p. 138-145, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular Epidemiology of Genital Chlamydia trachomatis Infection in High-Risk Women in Senegal, West Africa

Katharine Sturm-Ramirez,1 Hunter Brumblay,1 Khady Diop,2 Aissatou Guèye-Ndiaye,2 Jean-Louis Sankalé,1 Ibou Thior,1 Ibrahima N'Doye,3 Chung-Cheng Hsieh,4 Souleymane Mboup,2 and Phyllis J. Kanki1,*

Department of Immunology and Infectious Diseases, Harvard School of Public Health and Harvard AIDS Institute, Boston, Massachusetts1; and Laboratoire de Bactériologie-Virologie, Faculté Mixte de Médecine et de Pharmacie, Université Cheikh Anta Diop,2 and Institut Hygiène Sociale,3 Dakar, Senegal; and Division of Biostatistics and Epidemiology, University of Massachusetts Cancer Center, Worcester, Massachusetts4

Received 26 July 1999/Returned for modification 14 September 1999/Accepted 4 October 1999

The prevalence and heterogeneity of Chlamydia trachomatis infections in a cohort of female sex workers in Dakar (Senegal) were determined by using endocervical-swab-based PCR DNA amplification assays. The overall prevalence of cervical chlamydial infection was 28.5% (206 of 722), and most of these infections were asymptomatic. An increased number of sexual partners was significantly associated with infection (adjusted odds ratio [AOR] = 1.37; 95% confidence interval [CI] = 1.06 to 1.77), while the presence of a yeast infection was negatively associated with chlamydial infection (AOR = 0.28; 95% CI = 0.10 to 0.83). Six different C. trachomatis genotypes were identified based on phylogenetic analysis of the omp1 gene sequences. Interestingly, genotype E predominated (47.6%) and was not associated with visible signs of cervical inflammation compared to non-E genotypes (P < 0.05). Overall, the high rate of asymptomatic C. trachomatis infection by genotype E may suggest genotype-specific properties that confer a transmission advantage in this high risk population.

* Corresponding author. Mailing address: Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Ave., Boston, MA 02115. Phone: (617) 432-1267. Fax: (617) 432-3575. E-mail: pkanki{at}hsph.harvard.edu.

Journal of Clinical Microbiology, January 2000, p. 138-145, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nunes, A., Borrego, M. J., Nunes, B., Florindo, C., Gomes, J. P. (2009). Evolutionary Dynamics of ompA, the Gene Encoding the Chlamydia trachomatis Key Antigen. J. Bacteriol. 191: 7182-7192 [Abstract] [Full Text]  
  • Petrovay, F., Balla, E., Nemeth, I., Gonczol, E. (2009). Genotyping of Chlamydia trachomatis from the endocervical specimens of high-risk women in Hungary. J Med Microbiol 58: 760-764 [Abstract] [Full Text]  
  • Klint, M., Fuxelius, H.-H., Goldkuhl, R. R., Skarin, H., Rutemark, C., Andersson, S. G. E., Persson, K., Herrmann, B. (2007). High-Resolution Genotyping of Chlamydia trachomatis Strains by Multilocus Sequence Analysis. J. Clin. Microbiol. 45: 1410-1414 [Abstract] [Full Text]  
  • Klint, M., Lofdahl, M., Ek, C., Airell, A., Berglund, T., Herrmann, B. (2006). Lymphogranuloma Venereum Prevalence in Sweden among Men Who Have Sex with Men and Characterization of Chlamydia trachomatis ompA Genotypes. J. Clin. Microbiol. 44: 4066-4071 [Abstract] [Full Text]  
  • Hsu, M.-C., Tsai, P.-Y., Chen, K.-T., Li, L.-H., Chiang, C.-C., Tsai, J.-J., Ke, L.-Y., Chen, H.-Y., Li, S.-Y. (2006). Genotyping of Chlamydia trachomatis from clinical specimens in Taiwan.. J Med Microbiol 55: 301-308 [Abstract] [Full Text]  
  • Lysen, M., Osterlund, A., Rubin, C.-J., Persson, T., Persson, I., Herrmann, B. (2004). Characterization of ompA Genotypes by Sequence Analysis of DNA from All Detected Cases of Chlamydia trachomatis Infections during 1 Year of Contact Tracing in a Swedish County. J. Clin. Microbiol. 42: 1641-1647 [Abstract] [Full Text]  
  • Ngandjio, A., Clerc, M., Fonkoua, M. C., Thonnon, J., Lunel, F., Bebear, C., Bianchi, A., de Barbeyrac, B. (2004). Restriction endonuclease patterns of the omp1 gene of reference Chlamydia trachomatis strains and characterization of isolates from Cameroonian students. J Med Microbiol 53: 47-50 [Abstract] [Full Text]  
  • Ngandjio, A., Clerc, M., Fonkoua, M. C., Thonnon, J., Njock, F., Pouillot, R., Lunel, F., Bebear, C., de Barbeyrac, B., Bianchi, A. (2003). Screening of Volunteer Students in Yaounde (Cameroon, Central Africa) for Chlamydia trachomatis Infection and Genotyping of Isolated C. trachomatis Strains. J. Clin. Microbiol. 41: 4404-4407 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»