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Journal of Clinical Microbiology, January 2000, p. 138-145, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular Epidemiology of Genital Chlamydia trachomatis Infection in High-Risk Women in Senegal, West Africa

Katharine Sturm-Ramirez,1 Hunter Brumblay,1 Khady Diop,2 Aissatou Guèye-Ndiaye,2 Jean-Louis Sankalé,1 Ibou Thior,1 Ibrahima N'Doye,3 Chung-Cheng Hsieh,4 Souleymane Mboup,2 and Phyllis J. Kanki1,*

Department of Immunology and Infectious Diseases, Harvard School of Public Health and Harvard AIDS Institute, Boston, Massachusetts1; and Laboratoire de Bactériologie-Virologie, Faculté Mixte de Médecine et de Pharmacie, Université Cheikh Anta Diop,2 and Institut Hygiène Sociale,3 Dakar, Senegal; and Division of Biostatistics and Epidemiology, University of Massachusetts Cancer Center, Worcester, Massachusetts4

Received 26 July 1999/Returned for modification 14 September 1999/Accepted 4 October 1999

The prevalence and heterogeneity of Chlamydia trachomatis infections in a cohort of female sex workers in Dakar (Senegal) were determined by using endocervical-swab-based PCR DNA amplification assays. The overall prevalence of cervical chlamydial infection was 28.5% (206 of 722), and most of these infections were asymptomatic. An increased number of sexual partners was significantly associated with infection (adjusted odds ratio [AOR] = 1.37; 95% confidence interval [CI] = 1.06 to 1.77), while the presence of a yeast infection was negatively associated with chlamydial infection (AOR = 0.28; 95% CI = 0.10 to 0.83). Six different C. trachomatis genotypes were identified based on phylogenetic analysis of the omp1 gene sequences. Interestingly, genotype E predominated (47.6%) and was not associated with visible signs of cervical inflammation compared to non-E genotypes (P < 0.05). Overall, the high rate of asymptomatic C. trachomatis infection by genotype E may suggest genotype-specific properties that confer a transmission advantage in this high risk population.

* Corresponding author. Mailing address: Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Ave., Boston, MA 02115. Phone: (617) 432-1267. Fax: (617) 432-3575. E-mail: pkanki{at}hsph.harvard.edu.

Journal of Clinical Microbiology, January 2000, p. 138-145, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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