This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Polacheck, I.
Right arrow Articles by Coleman, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Polacheck, I.
Right arrow Articles by Coleman, D. C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2000, p. 170-174, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Recovery of Candida dubliniensis from Non-Human Immunodeficiency Virus-Infected Patients in Israel

Itzhack Polacheck,1 Jacob Strahilevitz,1 Derek Sullivan,2 Samantha Donnelly,2 Ira F. Salkin,3 and David C. Coleman2,*

Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1; Department of Oral Medicine and Oral Pathology, School of Dental Science and Dublin Dental Hospital, Trinity College, University of Dublin, Dublin 2, Republic of Ireland2; and Wadsworth Center, New York State Department of Health, Albany, New York3

Received 29 July 1999/Accepted 14 October 1999

Candida dubliniensis is a recently discovered yeast species principally associated with carriage and disease in the oral cavities of human immunodeficiency virus (HIV)-infected individuals. To date the majority of isolates of this species have been identified in Europe and North America. In this study, five Candida isolates recovered from separate HIV-negative hospitalized patients in Jerusalem, Israel, were presumptively identified as C. dubliniensis on the basis of their dark green coloration when grown on CHROMagar Candida medium. Their identification was confirmed by a variety of techniques, including carbohydrate assimilation profiles, absence of growth at 45°C, positive reaction with C. dubliniensis-specific antibodies as determined by indirect immunofluorescence analysis, and positive amplification with C. dubliniensis-specific PCR primers. All five strains were shown to be susceptible to a range of antifungal agents, including fluconazole. One of the five isolates was recovered from urine specimens, while the remaining four were recovered from upper respiratory tract and oral samples. While none of the patients was HIV positive, all were receiving broad-spectrum antibacterials at the time isolates of C. dubliniensis were obtained from clinical specimens. This study describes the first isolates of C. dubliniensis from the Middle East and confirms that this yeast can be associated with carriage and infection in the absence of HIV infection.

* Corresponding author. Mailing address: University of Dublin, Microbiology Research Laboratory, Department of Oral Medicine and Oral Pathology, School of Dental Science, Trinity College, Dublin 2, Republic of Ireland. Phone: 353 1 6127276. Fax: 353 1 671 1255. E-mail: dcoleman{at}dental.tcd.ie.

Journal of Clinical Microbiology, January 2000, p. 170-174, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • McManus, B. A., Moran, G. P., Higgins, J. A., Sullivan, D. J., Coleman, D. C. (2009). A Ser29Leu Substitution in the Cytosine Deaminase Fca1p Is Responsible for Clade-Specific Flucytosine Resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 53: 4678-4685 [Abstract] [Full Text]  
  • McManus, B. A., Coleman, D. C., Moran, G., Pinjon, E., Diogo, D., Bougnoux, M.-E., Borecka-Melkusova, S., Bujdakova, H., Murphy, P., d'Enfert, C., Sullivan, D. J. (2008). Multilocus Sequence Typing Reveals that the Population Structure of Candida dubliniensis Is Significantly Less Divergent than That of Candida albicans. J. Clin. Microbiol. 46: 652-664 [Abstract] [Full Text]  
  • Al Mosaid, A., Sullivan, D. J., Polacheck, I., Shaheen, F. A., Soliman, O., Al Hedaithy, S., Al Thawad, S., Kabadaya, M., Coleman, D. C. (2005). Novel 5-Flucytosine-Resistant Clade of Candida dubliniensis from Saudi Arabia and Egypt Identified by Cd25 Fingerprinting. J. Clin. Microbiol. 43: 4026-4036 [Abstract] [Full Text]  
  • Khan, Z. U., Ahmad, S., Mokaddas, E., Chandy, R. (2004). Tobacco Agar, a New Medium for Differentiating Candida dubliniensis from Candida albicans. J. Clin. Microbiol. 42: 4796-4798 [Abstract] [Full Text]  
  • Ahmad, S., Khan, Z., Mokaddas, E., Khan, Z. U. (2004). Isolation and molecular identification of Candida dubliniensis from non-human immunodeficiency virus-infected patients in Kuwait. J Med Microbiol 53: 633-637 [Abstract] [Full Text]  
  • Al Mosaid, A., Sullivan, D. J., Coleman, D. C. (2003). Differentiation of Candida dubliniensis from Candida albicans on Pal's Agar. J. Clin. Microbiol. 41: 4787-4789 [Abstract] [Full Text]  
  • Pinjon, E., Moran, G. P., Jackson, C. J., Kelly, S. L., Sanglard, D., Coleman, D. C., Sullivan, D. J. (2003). Molecular Mechanisms of Itraconazole Resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 47: 2424-2437 [Abstract] [Full Text]  
  • Fotedar, R., Al Hedaithy, S. S. A. (2003). Candida dubliniensis at a University Hospital in Saudi Arabia. J. Clin. Microbiol. 41: 1907-1911 [Abstract] [Full Text]  
  • Mosca, C. O., Moragues, M. D., Llovo, J., Al Mosaid, A., Coleman, D. C., Ponton, J. (2003). Casein Agar: a Useful Medium for Differentiating Candida dubliniensis from Candida albicans. J. Clin. Microbiol. 41: 1259-1262 [Abstract] [Full Text]  
  • Fitzgerald, D. H., Coleman, D. C., O'Connell, B. C. (2003). Susceptibility of Candida dubliniensis to Salivary Histatin 3. Antimicrob. Agents Chemother. 47: 70-76 [Abstract] [Full Text]  
  • Selvarangan, R., Limaye, A. P., Cookson, B. T. (2002). Rapid Identification and Differentiation of Candida albicans and Candida dubliniensis by Capillary-Based Amplification and Fluorescent Probe Hybridization. J. Clin. Microbiol. 40: 4308-4312 [Abstract] [Full Text]  
  • Moran, G., Sullivan, D., Morschhauser, J., Coleman, D. (2002). The Candida dubliniensis CdCDR1 Gene Is Not Essential for Fluconazole Resistance. Antimicrob. Agents Chemother. 46: 2829-2841 [Abstract] [Full Text]  
  • Martinez, M., Lopez-Ribot, J. L., Kirkpatrick, W. R., Coco, B. J., Bachmann, S. P., Patterson, T. F. (2002). Replacement of Candida albicans with C. dubliniensis in Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis Treated with Fluconazole. J. Clin. Microbiol. 40: 3135-3139 [Abstract] [Full Text]  
  • Perea, S., Lopez-Ribot, J. L., Wickes, B. L., Kirkpatrick, W. R., Dib, O. P., Bachmann, S. P., Keller, S. M., Martinez, M., Patterson, T. F. (2002). Molecular Mechanisms of Fluconazole Resistance in Candida dubliniensis Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis. Antimicrob. Agents Chemother. 46: 1695-1703 [Abstract] [Full Text]  
  • Gee, S. F., Joly, S., Soll, D. R., Meis, J. F. G. M., Verweij, P. E., Polacheck, I., Sullivan, D. J., Coleman, D. C. (2002). Identification of Four Distinct Genotypes of Candida dubliniensis and Detection of Microevolution In Vitro and In Vivo. J. Clin. Microbiol. 40: 556-574 [Abstract] [Full Text]  
  • Moragues, M. D., Omaetxebarria, M. J., Elguezabal, N., Bikandi, J., Quindos, G., Coleman, D. C., Ponton, J. (2001). Serological Differentiation of Experimentally Induced Candida dubliniensis and Candida albicans Infections. J. Clin. Microbiol. 39: 2999-3001 [Abstract] [Full Text]  
  • Staib, P., Moran, G. P., Sullivan, D. J., Coleman, D. C., Morschhäuser, J. (2001). Isogenic Strain Construction and Gene Targeting in Candida dubliniensis. J. Bacteriol. 183: 2859-2865 [Abstract] [Full Text]  
  • Al Mosaid, A., Sullivan, D., Salkin, I. F., Shanley, D., Coleman, D. C. (2001). Differentiation of Candida dubliniensis from Candida albicans on Staib Agar and Caffeic Acid-Ferric Citrate Agar. J. Clin. Microbiol. 39: 323-327 [Abstract] [Full Text]  
  • Stevens, D. A., Coleman, D. C., Sullivan, D. J. (2001). First Report of Candida dubliniensis in the Middle East. J. Clin. Microbiol. 39: 416-416 [Full Text]  
  • Park, S., Wong, M., Marras, S. A. E., Cross, E. W., Kiehn, T. E., Chaturvedi, V., Tyagi, S., Perlin, D. S. (2000). Rapid Identification of Candida dubliniensis Using a Species-Specific Molecular Beacon. J. Clin. Microbiol. 38: 2829-2836 [Abstract] [Full Text]  
  • Meis, J. F. G. M., Verduyn Lunel, F. M., Verweij, P. E., Voss;, A., Coleman, D. (2000). One-Year Prevalence of Candida dublinienis in a Dutch University Hospital. J. Clin. Microbiol. 38: 3139-3140 [Full Text]  
  • Jabra-Rizk, M. A., Falkler, W. A. Jr., Merz, W. G., Baqui, A. A. M. A., Kelley, J. I., Meiller, T. F. (2000). Retrospective Identification and Characterization of Candida dubliniensis Isolates among Candida albicans Clinical Laboratory Isolates from Human Immunodeficiency Virus (HIV)-Infected and Non-HIV-Infected Individuals. J. Clin. Microbiol. 38: 2423-2426 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»