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Journal of Clinical Microbiology, January 2000, p. 170-174, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Recovery of Candida dubliniensis from Non-Human Immunodeficiency Virus-Infected Patients in Israel

Itzhack Polacheck,1 Jacob Strahilevitz,1 Derek Sullivan,2 Samantha Donnelly,2 Ira F. Salkin,3 and David C. Coleman2,*

Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel1; Department of Oral Medicine and Oral Pathology, School of Dental Science and Dublin Dental Hospital, Trinity College, University of Dublin, Dublin 2, Republic of Ireland2; and Wadsworth Center, New York State Department of Health, Albany, New York3

Received 29 July 1999/Accepted 14 October 1999

Candida dubliniensis is a recently discovered yeast species principally associated with carriage and disease in the oral cavities of human immunodeficiency virus (HIV)-infected individuals. To date the majority of isolates of this species have been identified in Europe and North America. In this study, five Candida isolates recovered from separate HIV-negative hospitalized patients in Jerusalem, Israel, were presumptively identified as C. dubliniensis on the basis of their dark green coloration when grown on CHROMagar Candida medium. Their identification was confirmed by a variety of techniques, including carbohydrate assimilation profiles, absence of growth at 45°C, positive reaction with C. dubliniensis-specific antibodies as determined by indirect immunofluorescence analysis, and positive amplification with C. dubliniensis-specific PCR primers. All five strains were shown to be susceptible to a range of antifungal agents, including fluconazole. One of the five isolates was recovered from urine specimens, while the remaining four were recovered from upper respiratory tract and oral samples. While none of the patients was HIV positive, all were receiving broad-spectrum antibacterials at the time isolates of C. dubliniensis were obtained from clinical specimens. This study describes the first isolates of C. dubliniensis from the Middle East and confirms that this yeast can be associated with carriage and infection in the absence of HIV infection.

* Corresponding author. Mailing address: University of Dublin, Microbiology Research Laboratory, Department of Oral Medicine and Oral Pathology, School of Dental Science, Trinity College, Dublin 2, Republic of Ireland. Phone: 353 1 6127276. Fax: 353 1 671 1255. E-mail: dcoleman{at}dental.tcd.ie.

Journal of Clinical Microbiology, January 2000, p. 170-174, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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