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Journal of Clinical Microbiology, January 2000, p. 389-392, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Distribution and Antigenicity of Fibronectin Binding Proteins (SfbI and SfbII) of Streptococcus pyogenes Clinical Isolates from the Northern Territory, Australia

Alison M. Goodfellow,1 Megan Hibble,1 Susanne R. Talay,2 Bernd Kreikemeyer,2,dagger Bart J. Currie,1 Kadaba S. Sriprakash,1 and Gursharan S. Chhatwal2,*

Menzies School of Health Research, Casuarina, Australia,1 and Department of Microbial Pathogenesis and Vaccine Research, Technical University/GBF National Research Centre for Biotechnology, Braunschweig, Germany2

Received 28 June 1999/Returned for modification 11 September 1999/Accepted 23 September 1999

Fibronectin binding proteins play an important role in the adherence and invasion of group A streptococci (GAS). Genotypically distinct GAS isolates were screened for the presence and expression of two streptococcal fibronectin binding protein genes, sfbI and sfbII. Of the tested strains, 64 and 36% were shown to harbor and express the sfbI and sfbII genes, respectively. All sfbII-positive strains tested were also positive for sfbI, but only 28% of the sfbII-negative strains were positive for sfbI. High levels of immunoglobulin G antibodies to both SfbI and SfbII were found in sera from 80 subjects with defined streptococcal infections.

* Corresponding author. Mailing address: Department of Microbial Pathogenesis and Vaccine Research, Technical University/GBF National Centre for Biotechnology, Spielmannstrasse 7, D-38106 Braunschweig, Germany. Phone: 49 531 391 5860. Fax: 49 531 391 5858. E-mail: gsc{at}gbf.de.

dagger Present address: Institut für Mikrobiologie und Immunologie, Universität Ulm, Ulm, Germany.

Journal of Clinical Microbiology, January 2000, p. 389-392, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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