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Journal of Clinical Microbiology, January 2000, p. 450-452, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

A Clonal Subpopulation of Leptospira interrogans Sensu Stricto Is the Major Cause of Leptospirosis Outbreaks in Brazil

M. M. Pereira,1,* M. G. S. Matsuo,2 A. R. Bauab,2 S. A. Vasconcelos,3 Z. M. Moraes,3 G. Baranton,4 and I. Saint Girons4

National Reference Center for Leptospirosis, Instituto Oswaldo Cruz, Rio de Janeiro,1 and Center for Zoonosis Control2 and University of São Paulo,3 São Paulo, Brazil, and Unité de Bactériologie Moléculaire et Médicale, Institut Pasteur, 75724 Paris, France4

Received 28 July 1999/Accepted 22 September 1999

Leptospira is a highly diverse genus comprising many species and serogroups in Brazil as well as all over the world. However, a study by arbitrarily primed PCR of 44 leptospiral strains isolated from humans during three different outbreaks in Brazilian urban centers reveals that 43 of 44 isolates exhibit very similar fingerprints. Analysis of these isolates indicates that they belong to a clonal subpopulation of Leptospira interrogans sensu stricto.


* Corresponding author. Mailing address: Department of Bacteriology, Oswaldo Cruz Institute/FIOCRUZ, Avenida Brasil, 4365, 21045-900. Rio de Janeiro, Brazil. Phone: 55-21-270-3545. Fax: 55-21-590-3545. E-mail: mpereira{at}gene.dbbm.fiocruz.br.


Journal of Clinical Microbiology, January 2000, p. 450-452, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



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