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Journal of Clinical Microbiology, January 2000, p. 68-70, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

CagA Antibodies in Japanese Children with Nodular Gastritis or Peptic Ulcer Disease

Seiichi Kato,1,* Toshiro Sugiyama,2 Mineo Kudo,2 Kenji Ohnuma,1 Kyoko Ozawa,1 Kazuie Iinuma,1 Masahiro Asaka,2 and Martin J. Blaser3

Department of Pediatrics, Tohoku University School of Medicine, Sendai,1 and Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo,2 Japan, and Departments of Medicine and Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee3

Received 26 July 1999/Returned for modification 31 August 1999/Accepted 9 October 1999

cagA+ Helicobacter pylori strains have been linked to more severe gastric inflammation, peptic ulcer disease, and gastric cancer in adults, but there have been few studies of cagA in children. We examined the relationship between H. pylori cagA status and clinical status in Japanese children. Forty H. pylori-positive children were studied: 15 with nodular gastritis, 5 with gastric ulcers, and 20 with duodenal ulcers. H. pylori status was confirmed by biopsy-based tests and serum anti-H. pylori immunoglobulin G (IgG) antibody. As controls, 77 asymptomatic children with sera positive for anti-H. pylori IgG were enrolled. Levels of IgG antibodies to CagA in serum were measured by an antigen-specific enzyme-linked immunosorbent assay. In 16 patients with successful H. pylori eradication, posttreatment levels of CagA and H. pylori IgG antibodies also were studied. The CagA antibody seropositivities of asymptomatic controls (81.8%) and patients with nodular gastritis, gastric ulcers, and duodenal ulcers (80.0 to 95.0%) were not significantly different. Compared with pretreatment levels of CagA antibodies, posttreatment levels decreased progressively and significantly. We conclude that, as in Japanese adults, a high prevalence of cagA+ H. pylori strains was found in Japanese children, and that there was no association with nodular gastritis or peptic ulcer disease. In the assessment of eradicative therapies, monitoring of serum anti-CagA antibodies does not appear to offer any direct benefit over monitoring of anti-H. pylori antibodies.

* Corresponding author. Mailing address: Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Phone: 81-22-717-7287. Fax: 81-22-717-7290. E-mail: skato{at}ped.med.tohoku.ac.jp.

Journal of Clinical Microbiology, January 2000, p. 68-70, Vol. 38, No. 1
0095-1137/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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