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Journal of Clinical Microbiology, October 2000, p. 3722-3728, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Helicobacter aurati sp. nov., a Urease-Positive Helicobacter Species Cultured from Gastrointestinal Tissues of Syrian Hamsters

M. M. Patterson,1 M. D. Schrenzel,1,dagger Y. Feng,1 S. Xu,1 F. E. Dewhirst,2 B. J. Paster,2 S. A. Thibodeau,1,3 J. Versalovic,1,3,4 and J. G. Fox1,*

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 021391; Department of Molecular Genetics, Forsyth Institute,2 and Department of Pathology, Harvard Medical School,4 Boston, Massachusetts 02115; and Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 021143

Received 22 May 2000/Accepted 9 August 2000

A novel helicobacter with the proposed name Helicobacter aurati (type strain MIT 97-5075c) has been isolated from the inflamed stomachs and ceca of adult Syrian hamsters. The new species is fusiform with multiple bipolar sheathed flagella and periplasmic fibers; it contains urease and gamma-glutamyl transpeptidase. By 16S rRNA sequencing and repetitive element PCR-based DNA fingerprinting, it was found that H. aurati represents a distinct taxon and clusters with Helicobacter muridarum, Helicobacter hepaticus, and Helicobacter sp. MIT 94-022. H. aurati was recovered from hamsters housed in various research and vendor facilities. Further studies are necessary to define its association with disease and other microbiota in hamsters, as well as its impact on research projects involving hamsters. H. aurati (GenBank accession number AF297868) can be used in animal experiments to define the factors that are important for gastric helicobacter pathogenesis.

* Corresponding author. Mailing address: Division of Comparative Medicine, Bldg. 16-825, Massachusetts Institute of Technology, Cambridge, MA 02139. Phone: (617) 253-1757. Fax: (617) 258-5708. E-mail: jgfox{at}mit.edu.

dagger Present address: Zoological Society of San Diego, CRES, San Diego, CA 92101-1635.

Journal of Clinical Microbiology, October 2000, p. 3722-3728, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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