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Journal of Clinical Microbiology, October 2000, p. 3849-3852, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

G Protein Variation in Respiratory Syncytial Virus Group A Does Not Correlate with Clinical Severity

A. H. Brandenburg,1,dagger R. van Beek,1 H. A. Moll,2 A. D. M. E. Osterhaus,1,* and E. C. J. Claas1,Dagger

Institute of Virology, Erasmus University Hospital, 3000 DR Rotterdam,1 and the Department of Paediatrics, Sophia Children's Hospital, 3015 GE Rotterdam,2 The Netherlands

Received 12 June 2000/Returned for modification 25 July 2000/Accepted 9 August 2000

Respiratory syncytial virus group A strain variations of 28 isolates from The Netherlands collected during three consecutive seasons were studied by analyzing G protein sequences. Several lineages circulated repeatedly and simultaneously during the respective seasons. No relationships were found between lineages on the one hand and clinical severity or age on the other.

* Corresponding author. Mailing address: Institute of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31-10-4088066. Fax: 31-10-4089485. E-mail: osterhaus{at}viro.fgg.eur.nl.

dagger Present address: LVF, 8917 EN Leeuwarden, The Netherlands.

Dagger Present address: Department of Virology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Journal of Clinical Microbiology, October 2000, p. 3849-3852, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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