JCM Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seijo Martinez, M.
Right arrow Articles by Visvesvara, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seijo Martinez, M.
Right arrow Articles by Visvesvara, G. S.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2000, p. 3892-3895, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Granulomatous Amebic Encephalitis in a Patient with AIDS: Isolation of Acanthamoeba sp. Group II from Brain Tissue and Successful Treatment with Sulfadiazine and Fluconazole

M. Seijo Martinez,1,* G. Gonzalez-Mediero,2 P. Santiago,3 A. Rodriguez de Lope,4 J. Diz,5 C. Conde,4 and G. S. Visvesvara6

Departments of Neurology1 and Internal Medicine,5 Complexo Hospitalario de Pontevedra, and Departments of Microbiology,2 Pathology,3 and Neurosurgery,4 Hospital Xeral-Cies, Vigo, Spain, and Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia6

Received 4 February 2000/Returned for modification 23 March 2000/Accepted 23 June 2000

A patient with AIDS, treated with highly active antiretroviral therapy and trimethoprim-sulfamethoxazole, presented with confusion, a hemifield defect, and a mass lesion in the right occipital lobe. A brain biopsy confirmed granulomatous amebic encephalitis (GAE) due to Acanthamoeba castellanii. The patient was treated with fluconazole and sulfadiazine, and the lesion was surgically excised. This is the first case of AIDS-associated GAE responding favorably to therapy. The existence of a solitary brain lesion, absence of other sites of infection, and intense cellular response in spite of a very low CD4 count conditioned the favorable outcome. We review and discuss the diagnostic microbiologic options for the laboratory diagnosis of infections due to free-living amebae.


* Corresponding author. Mailing address: Neurology Service, Complexo Hospitalario de Pontevedra, Loureiro Crespo 2, Pontevedra Spain 36001. Phone: 34 986 800 000. Fax: 34 986 80 70 52. E-mail: mseijom{at}meditex.es.


Journal of Clinical Microbiology, October 2000, p. 3892-3895, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2000 by the American Society for Microbiology. All rights reserved.