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Journal of Clinical Microbiology, October 2000, p. 3900-3901, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Failure To Detect Circulating Aspergillus Markers in a Patient with Chronic Granulomatous Disease and Invasive Aspergillosis

Paul E. Verweij,1,* Corry M. Weemaes,2 Jo H. A. J. Curfs,1 Stephane Bretagne,3 and Jacques F. G. M. Meis1,4

Department of Medical Microbiology1 and Pediatrics,2 University Medical Center Nijmegen, and Department of Medical Microbiology and Public Health, Canisius Wilhelmina Hospital,4 Nijmegen, The Netherlands, and Laboratoire de Parasitologie-Mycologie, Hôpital Henri Mondor, Créteil, France3

Received 8 May 2000/Returned for modification 22 June 2000/Accepted 10 July 2000

We report a patient with chronic granulomatous disease who developed invasive pulmonary aspergillosis and a subphrenic abscess. During treatment, high levels of Aspergillus antigen were detected in the abscess, but circulating antigen and Aspergillus DNA were undetectable in the serum.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.

Journal of Clinical Microbiology, October 2000, p. 3900-3901, Vol. 38, No. 10
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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