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Journal of Clinical Microbiology, November 2000, p. 4102-4107, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mycobacterium heckeshornense sp. nov., a New Pathogenic Slowly Growing Mycobacterium sp. Causing Cavitary Lung Disease in an Immunocompetent Patient

Andreas Roth,1,* Udo Reischl,2 Nicolas Schönfeld,3 Ludmila Naumann,2 Stefan Emler,4 Marga Fischer,1 Harald Mauch,1 Robert Loddenkemper,3 and Reiner M. Kroppenstedt5

Institut für Mikrobiologie und Immunologie1 and Pneumologie II,3 Lungenklinik Heckeshorn, 14109 Berlin, Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, 93053 Regensburg,2 and Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, 38124 Braunschweig,5 Germany, and Medica Medizinische Laboratorien, 8024 Zürich, Switzerland4

Received 15 May 2000/Returned for modification 15 July 2000/Accepted 28 August 2000

A pathogenic scotochromogenic Mycobacterium xenopi-like organism was isolated from the lung of an immunocompetent young woman. This pathogen caused severe bilateral cavitary lung disease, making two surgical interventions necessary after years of chronic disease. This case prompted us to characterize this mycobacterium by a polyphasic taxonomic approach. The isolate contained chemotaxonomic markers which were typical for the genus Mycobacterium, i.e., the meso isomer of 2,6-diaminopimelic acid, arabinose, and galactose as diagnostic whole-cell sugars, MK-9(H2) as the principal isoprenoid quinone, a mycolic acid pattern of alpha -mycolates, ketomycolates, and wax ester mycolates, unbranched saturated and unsaturated fatty acids plus a significant amount of tuberculostearic acid, and small amounts of a C20:0 secondary alcohol. On the basis of its unique 16S rRNA and 16S-23S spacer gene sequences, we propose that the isolate should be assigned to a new species, Mycobacterium heckeshornense. This novel species is phylogenetically closely related to M. xenopi. The type strain of M. heckeshornense is strain S369 (DSM 44428T). The GenBank accession number of the 16S rRNA gene of M. heckeshornense is AF174290.

* Corresponding author. Mailing address: Institute für Mikrobiologie und Immunologie, Lungenklinik Heckeshorn, Zum Heckeshorn 33, D 14109 Berlin, Germany. Phone: 49-30-8002 2254. Fax: 49-30-8002 2299. E-mail: mikromau{at}zedat.fu-berlin.de.

Journal of Clinical Microbiology, November 2000, p. 4102-4107, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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