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Journal of Clinical Microbiology, November 2000, p. 4208-4210, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Granulocytic Ehrlichiae in Ixodes persulcatus Ticks from an Area in China Where Lyme Disease Is Endemic

Wu-Chun Cao,1,* Qiu-Min Zhao,1 Pan-He Zhang,1 J. Stephen Dumler,2 Xi-Tan Zhang,1 Li-Qun Fang,1 and Hong Yang1

Institute of Microbiology and Epidemiology, Fengtai District, Beijing 100071, China,1 and Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 212012

Received 17 April 2000/Returned for modification 12 July 2000/Accepted 5 September 2000

A total of 372 adult Ixodes persulcatus ticks were collected from vegetation in a forest area of Heilongjiang Province in northeastern China, where Lyme disease is known to be endemic. The ticks were examined for the presence of granulocytic ehrlichiae by heminested PCR with primers derived from the 16S rRNA gene. Of 310 ticks obtained from the Dahe forestry farm, two pools (each containing 5 ticks) were found positive, with a minimum infection rate of 0.6%. Ehrlichial DNA was also detected in one female (1.6%) of 62 ticks collected from the Yulin forestry farm. The overall minimum infection rate of the 372 I. persulcatus adults was 0.8%. The nucleotide sequences of 919-bp PCR products from the three positive tick specimens were identical to each other and very closely related to the members of the Ehrlichia phagocytophila genogroup. This is the first identification of granulocytic ehrlichiae in ticks in Asia and the first report of infection in I. persulcatus anywhere.

* Corresponding author. Mailing address: Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da-Jie St., Fengtai District, Beijing 100071, People's Republic of China. Phone: (086) 10-63862060. Fax: (086) 10-63812060. E-mail: caowc{at}nic.bmi.ac.cn.

Journal of Clinical Microbiology, November 2000, p. 4208-4210, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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