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Journal of Clinical Microbiology, November 2000, p. 4274-4276, Vol. 38, No. 11
Chlamydia Research Laboratory, Department of
Pediatrics, Division of Infectious Diseases, SUNY Health Science Center
at Brooklyn, Brooklyn, New York1;
Department of Neurology, MCP Hahnemann University,
Philadelphia, Pennsylvania2; and
Department of Virology, Umeå University, Umeå,
Sweden3
Received 11 July 2000/Returned for modification 9 August
2000/Accepted 22 August 2000
We investigated the presence of Chlamydia pneumoniae in
81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR
amplification of the organism in a subset of 19 brain specimens were
also performed in two separate laboratories. All results were negative.
Thus, this study on a large number of brain tissues suggests that
C. pneumoniae is not involved in inflammatory demyelination.
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Is Chlamydia pneumoniae Present in Brain
Lesions of Patients with Multiple Sclerosis?
*
Corresponding author. Mailing address: Department of
Neurology, MS 423, MCP Hahnemann University, 245 North 15th St.,
Philadelphia, PA 19102. Phone: (215) 762-1898. Fax: (215) 762-3161. E-mail: bernadette.kalman{at}drexel.edu.
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